The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging
Suzuki R, Tan X, Szymanska K, Kubikova N, Perez C, Wells D, Oktay K. The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging. Cell Death Discovery 2024, 10: 302. PMID: 38914566, PMCID: PMC11196715, DOI: 10.1038/s41420-024-02041-z.Peer-Reviewed Original ResearchOocyte qualityAtaxia telangiectasia-mutatedOocyte agingMaintenance of oocyte qualityDNA double-strand breaksMeiosis in vitroPoor embryo developmentImpaired oocyte qualityATM functionMolecular cytogenetic analysisFormation of DNA DSBsDeath compared to controlsBlastocyst stageEmbryo cleavageDNA DSBsOvarian agingCytogenetic analysisResistance to genotoxic stressActive metaboliteNext-generation sequencingRates compared to controlsIn vitro cultureOocytesDNA DSB repairAge-induced decline