2022
PRESENCE OF BRCA MUTATIONS AND A PRE-CHEMOTHERAPY AMH LEVEL OF < 2ng/ML STRONGLY PREDICT RISK OF AMENORRHEA IN WOMEN WITH BREAST CANCER
Oktay K, Turan V, Bedoschi G, Goldfarb S, Bang H. PRESENCE OF BRCA MUTATIONS AND A PRE-CHEMOTHERAPY AMH LEVEL OF < 2ng/ML STRONGLY PREDICT RISK OF AMENORRHEA IN WOMEN WITH BREAST CANCER. Fertility And Sterility 2022, 118: e231. DOI: 10.1016/j.fertnstert.2022.08.652.Peer-Reviewed Original ResearchLaparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
Vash-Margita A, Szymanska-Vandendriessche K, Gunther K, Rodriguez-Buritica DF, Christison-Lagay E, Saluja S, Oktay KH. Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia. Fertility And Sterility 2022, 118: 982-984. PMID: 36154768, DOI: 10.1016/j.fertnstert.2022.08.005.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsOvarian tissue cryopreservationFertility preservationMonths of ageHormone levelsPrimordial folliclesAMH levelsMIU/Right ovaryTissue cryopreservationOvarian tissueReproductive endocrinologyOvarian tissue harvestingLower AMH levelsUneventful postoperative courseGood metabolic controlPelvic magnetic resonanceSubsequent histological examinationSmall antral folliclesPrimary ovarian insufficiencyTissue harvestingEffect of cauterizationYoung female childMagnetic resonance imaging (MRI) examsRare genetic disorder
2021
Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data
Turan V, Lambertini M, Lee D, Wang E, Clatot F, Karlan B, Demeestere I, Bang H, Oktay K. Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data. Journal Of Clinical Oncology 2021, 39: 2016-2024. PMID: 33891474, PMCID: PMC8260903, DOI: 10.1200/jco.20.02880.Peer-Reviewed Original ResearchConceptsIndividual patient-level dataSerum AMH levelsDiminished ovarian reservePatient-level dataAMH levelsOvarian reservePathogenic variantsGermline BRCA pathogenic variantLow serum AMH levelsAnti-Müllerian hormone levelsOral contraceptive pill useLower AMH levelsDecreased ovarian reserveBody mass indexContraceptive pill useBRCA pathogenic variantsEvaluable womenMass indexMean ageHormone levelsBreast cancerAffected womenPill useMeta-AnalysisYoung women
2020
Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer
Goldfarb S, Turan V, Bedoschi G, Taylan E, Abdo N, Cigler T, Bang H, Patil S, Dickler M, Oktay K. Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer. Breast Cancer Research And Treatment 2020, 185: 165-173. PMID: 32930927, PMCID: PMC7877450, DOI: 10.1007/s10549-020-05933-7.Peer-Reviewed Original ResearchConceptsAnti-Mullerian hormoneOvarian reserveAdjuvant chemotherapyBreast cancerAMH levelsChemotherapy regimensCompletion of ACSerum AMH levelsAdjuvant tamoxifenAMH recoveryChemotherapy groupPrimary diagnosisBaseline ageMethodsOne hundredAMH assessmentRegimensChemotherapyYoung womenTamoxifenSignificant recoveryCancerMixed effects modelsMonthsTreatment effectsWomenImpact of breast cancer chemotherapy on ovarian damage and recovery.
Goldfarb S, Bedoschi G, Turan V, Crown A, Abdo N, Dickler M, Oktay K. Impact of breast cancer chemotherapy on ovarian damage and recovery. Journal Of Clinical Oncology 2020, 38: e24059-e24059. DOI: 10.1200/jco.2020.38.15_suppl.e24059.Peer-Reviewed Original ResearchAMH recoveryBreast cancerBaseline AMHOvarian reserveNon-metastatic breast cancerBaseline AMH levelsTime of diagnosisBreast cancer patientsBreast cancer chemotherapyImpact of chemoImportant predictorCancer ptsChemo groupGonadotoxic chemoChemotherapy regimenOvarian damageSerum AMHAMH levelsStudy entryTamoxifen treatmentFertility preservationLow AMHProspective studyCancer patientsFuture fertility
2015
Menstruation is an unreliable surrogate in the assessment of ovarian damage by chemotherapy: a prospective longitudinal study with AMH levels as the gold standard
Bedoschi G, Goldfarb S, Quistorff J, Goswami S, Moy F, Dickler M, Oktay K. Menstruation is an unreliable surrogate in the assessment of ovarian damage by chemotherapy: a prospective longitudinal study with AMH levels as the gold standard. Fertility And Sterility 2015, 104: e262-e263. DOI: 10.1016/j.fertnstert.2015.07.825.Peer-Reviewed Original Research