2009
Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases.
Schalper K, Orellana J, Berthoud V, Sáez J. Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. Current Vascular Pharmacology 2009, 7: 486-505. PMID: 19485891, DOI: 10.2174/157016109789043937.Peer-Reviewed Original ResearchConceptsHuman genetic diseasesNormal cell functioningHemichannel activityMost cell typesConnexin mutantsForm homoTransmembrane proteinMembrane permeabilizationPlasma membraneLethal stimuliMembrane pathwaysCell functioningHuman diseasesCell deathCell typesGenetic diseasesMost cellsHemichannelsPannexinsSmall moleculesConnexinsTransportersPathological conditionsPathwayVertebrates
2008
Connexin Hemichannel Composition Determines the FGF-1–induced Membrane Permeability and Free [Ca2+]i Responses
Schalper K, Palacios-Prado N, Retamal M, Shoji K, Martínez A, Sáez J. Connexin Hemichannel Composition Determines the FGF-1–induced Membrane Permeability and Free [Ca2+]i Responses. Molecular Biology Of The Cell 2008, 19: 3501-3513. PMID: 18495870, PMCID: PMC2488314, DOI: 10.1091/mbc.e07-12-1240.Peer-Reviewed Original ResearchConceptsHeLa cellsC-terminusP38 MAP kinase-dependent pathwayMembrane permeabilityMAP kinase-dependent pathwayDifferent connexin typesKinase-dependent pathwayFGF-1HeLa transfectantsDiverse cellsRegulatory sitesCellular responsesCell surfaceCell permeabilizationHemichannelsConnexin typesSerum-free mediumCx26CellsPossible roleCell densityCx43Early intracellularPermeabilizationTransfectants
2007
Possible Involvement of Different Connexin43 Domains in Plasma Membrane Permeabilization Induced by Ischemia-Reperfusion
Retamal MA, Schalper KA, Shoji KF, Orellana JA, Bennett MV, Sáez JC. Possible Involvement of Different Connexin43 Domains in Plasma Membrane Permeabilization Induced by Ischemia-Reperfusion. The Journal Of Membrane Biology 2007, 218: 49-63. PMID: 17705051, DOI: 10.1007/s00232-007-9043-y.Peer-Reviewed Original Research