Role of HLA class-I antigen peptide loading complex components in immune evasion and treatment sensitivity in human lung cancer.
Costantini A, Ranjan K, Ferrone S, Schalper K. Role of HLA class-I antigen peptide loading complex components in immune evasion and treatment sensitivity in human lung cancer. Journal Of Clinical Oncology 2023, 41: 2623-2623. DOI: 10.1200/jco.2023.41.16_suppl.2623.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsHLA classSelective downregulationShorter OSICI resistanceMarker levelsStromal cellsLow marker levelTumor antigen recognitionEffector T cellsT cell infiltrationT cell levelsProtein levelsPeptide loading complexEarly-stage tumorsHuman lung cancerPeptide-HLA complexesLevels of TAPDeterminants of sensitivityLow CD8Checkpoint inhibitorsHuman NSCLCPresentation machineryClinicopathologic variablesLung cancer