2010
Cell membrane permeabilization via connexin hemichannels in living and dying cells
Sáez J, Schalper K, Retamal M, Orellana J, Shoji K, Bennett M. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Experimental Cell Research 2010, 316: 2377-2389. PMID: 20595004, DOI: 10.1016/j.yexcr.2010.05.026.Peer-Reviewed Original ResearchConceptsCell membrane permeabilityMembrane permeabilityComplex signaling cascadesConnexin hemichannelsDiverse cell typesCx HCsGap junction channelsVertebrate cellsCell membrane permeabilizationForm hemichannelsMembrane permeabilizationSignaling cascadesOpen probabilityJunction channelsCell typesCultured cellsExtracellular microenvironmentCell membraneHemichannelsMost cellsLow open probabilityStage dependencyUnitary conductanceSmall moleculesConnexins
2009
Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases.
Schalper K, Orellana J, Berthoud V, Sáez J. Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. Current Vascular Pharmacology 2009, 7: 486-505. PMID: 19485891, DOI: 10.2174/157016109789043937.Peer-Reviewed Original ResearchConceptsHuman genetic diseasesNormal cell functioningHemichannel activityMost cell typesConnexin mutantsForm homoTransmembrane proteinMembrane permeabilizationPlasma membraneLethal stimuliMembrane pathwaysCell functioningHuman diseasesCell deathCell typesGenetic diseasesMost cellsHemichannelsPannexinsSmall moleculesConnexinsTransportersPathological conditionsPathwayVertebrates