2017
Interleukin-8 in cancer pathogenesis, treatment and follow-up
Alfaro C, Sanmamed MF, Rodríguez-Ruiz ME, Teijeira Á, Oñate C, González Á, Ponz M, Schalper KA, Pérez-Gracia JL, Melero I. Interleukin-8 in cancer pathogenesis, treatment and follow-up. Cancer Treatment Reviews 2017, 60: 24-31. PMID: 28866366, DOI: 10.1016/j.ctrv.2017.08.004.Peer-Reviewed Original ResearchConceptsSerum concentrationsInterleukin-8IL-8 serum concentrationsPro-tumoral functionsCancer stem cellsTumor burdenLeukocyte infiltrateCancer immunotherapyIL-8Pharmacodynamic biomarkersTherapeutic combinationsTherapeutic strategiesMyeloid cellsTumor progressionCancer pathogenesisTumor cellsGrowth factorImmunotherapySuch interventionsChemokinesStem cellsCellsInfiltratesCXCR1/2Pathogenesis
2012
Modulation of gap junction channels and hemichannels by growth factors
Schalper K, Riquelme M, Brañes M, Martínez A, Vega J, Berthoud V, Bennett M, Sáez J. Modulation of gap junction channels and hemichannels by growth factors. Molecular Omics 2012, 8: 685-698. PMID: 22218428, DOI: 10.1039/c1mb05294b.Peer-Reviewed Original ResearchConceptsGap junction channelsTransduction pathwaysGrowth factor signal transduction pathwaysJunction channelsNumerous cellular processesCell-cell communicationCell-cell channelsGrowth factorSignal transduction pathwaysProtein kinase-dependent mechanismNormal cellular responseCellular transduction pathwaysKinase-dependent mechanismCell membrane receptorsGap junction hemichannelsCellular coordinationCellular processesProtein kinaseCellular responsesCell stageMembrane receptorsMembrane channelsCell typesFunctional consequencesChannel insertion