2016
Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer
Rehman JA, Han G, Carvajal-Hausdorf DE, Wasserman BE, Pelekanou V, Mani NL, McLaughlin J, Schalper KA, Rimm DL. Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer. Modern Pathology 2016, 30: 340-349. PMID: 27834350, PMCID: PMC5334264, DOI: 10.1038/modpathol.2016.186.Peer-Reviewed Original ResearchConceptsPD-L1 expressionPD-L1Immune cellsImmune cell PD-L1 expressionNon-small cell lung cancerNon-small cell lung cancer (NSCLC) casesCell lung cancer casesTumor cellsPD-L1 assessmentStromal immune cellsPD-L1 positivityCell lung cancerLung cancer patientsLung cancer casesRepresentative tumor areasPathologist scoresLikelihood of responseConcordance correlation coefficientRabbit monoclonal antibodyIntraclass correlation coefficientCancer patientsLung cancerImmunohistochemistry slidesCancer casesTumor tissue
2014
Overexpression of the HER2/neu Gene: A New Therapeutic Possibility for Patients With Advanced Gallbladder Cancer.
Roa I, de Toro G, Schalper K, de Aretxabala X, Churi C, Javle M. Overexpression of the HER2/neu Gene: A New Therapeutic Possibility for Patients With Advanced Gallbladder Cancer. Gastrointestinal Cancer Research : GCR 2014, 7: 42-8. PMID: 24799970, PMCID: PMC4007675.Peer-Reviewed Original ResearchHER2/neu overexpressionHER2/neu geneGallbladder cancerHER2/neuNeu overexpressionHER2/neu expressionNeu geneHer2/neu pathwaySubgroup of patientsWorse overall survivalAdvanced gallbladder cancerSingle large studyAnti-ErbB2 antibodyNew therapeutic possibilitiesGallbladder cancer casesASCO criteriaOverall survivalAdvanced cancerControl subjectsNeu expressionTargeted therapyEquivocal stainingBreast cancerCancer casesImmunohistochemical techniques