2022
Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia
Farrelly L, Zheng S, Schrode N, Topol A, Bhanu N, Bastle R, Ramakrishnan A, Chan J, Cetin B, Flaherty E, Shen L, Gleason K, Tamminga C, Garcia B, Li H, Brennand K, Maze I. Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia. Nature Communications 2022, 13: 2195. PMID: 35459277, PMCID: PMC9033776, DOI: 10.1038/s41467-022-29922-0.Peer-Reviewed Original ResearchConceptsHistone posttranslational modificationsPosttranslational modificationsUnbiased proteomic approachPluripotent stem cellsPatient-derived neuronsH2A.Z acetylationChromatin profilingHyperacetylated histonesFamily proteinsProteomic approachProtein interactionsHistone acetylationTranscriptional abnormalitiesEpigenetic factorsExtraterminal (BET) proteinsSZ casesRisk variantsHuman neuronsStem cellsAberrant roleProtein inhibitionBona fideTreatment of schizophreniaPostmortem human brainCritical role
2017
MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice
Mitchell A, Javidfar B, Pothula V, Ibi D, Shen E, Peter C, Bicks L, Fehr T, Jiang Y, Brennand K, Neve R, Gonzalez-Maeso J, Akbarian S. MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice. Molecular Psychiatry 2017, 23: 123-132. PMID: 28115742, PMCID: PMC5966823, DOI: 10.1038/mp.2016.254.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainChromatin ImmunoprecipitationCognition DisordersComputational BiologyDisease Models, AnimalEpigenomicsGene Expression RegulationGreen Fluorescent ProteinsHistonesMEF2 Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeuronsPolymorphism, Single NucleotideSchizophreniaTransduction, GeneticConceptsTherapeutic potentialPrefrontal projection neuronsNeuron-specific promoterUnexplored therapeutic potentialProjection neuronsDrug challengeDisease casesRelated disordersRisk architecturePrefrontal cortexSchizophreniaSingle nucleotide polymorphismsCognitive performancePsychiatric Genomics ConsortiumNeuronal genomeH3K4 hypermethylationRisk lociCognitive enhancement
2007
All β Cells Contribute Equally to Islet Growth and Maintenance
Brennand K, Huangfu D, Melton D. All β Cells Contribute Equally to Islet Growth and Maintenance. PLOS Biology 2007, 5: e163. PMID: 17535113, PMCID: PMC1877817, DOI: 10.1371/journal.pbio.0050163.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCell DifferentiationCell ProliferationFemaleGenes, ReporterGenetic MarkersGreen Fluorescent ProteinsHistonesIn Vitro TechniquesInsulin-Secreting CellsIslets of LangerhansMaleMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalMosaicismRecombinant Fusion ProteinsTetracyclineConceptsBeta-cell populationBeta cellsBeta-cell replicationHealthy adult miceBeta-cell poolCell populationsDifferentiated beta cellsStem cellsReplacement therapyCell replacement therapyAdult miceIslet growthΒ-cellsProtein expressionCell poolReplicative capacityCell replicationHepatocyte populationAdult stem cellsClonal analysisCellsLevel of fluorescenceFluorescent protein expressionPopulationDiabetes