2023
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain
Seah C, Brennand K. Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain. Cell Stem Cell 2023, 30: 239-241. PMID: 36868190, DOI: 10.1016/j.stem.2023.02.002.Peer-Reviewed Original Research
2022
Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection
Singh K, Martinez M, Lin J, Gregory J, Nguyen T, Abdelaal R, Kang K, Brennand K, Grünweller A, Ouyang Z, Phatnani H, Kielian M, Wendel H. Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection. Viruses 2022, 14: 1418. PMID: 35891396, PMCID: PMC9316442, DOI: 10.3390/v14071418.Peer-Reviewed Original ResearchConceptsAminoacyl-tRNA synthetasesHuman neuronal progenitor cellsUpstream ORFsStress responseCellular stress responseOpen reading frameCell stress responseSimultaneous RNA sequencingViral RNA genomeGene expression dataNeuronal progenitor cellsZika virusRibosome occupancyDengue virusGenome sequenceTRNA synthetasesReading frameRNA sequencingRNA translationRNA genomeTranslation capacityKey enzymeViral translationExpression dataRNA viruses
2017
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain
Zhou T, Tan L, Cederquist G, Fan Y, Hartley B, Mukherjee S, Tomishima M, Brennand K, Zhang Q, Schwartz R, Evans T, Studer L, Chen S. High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain. Cell Stem Cell 2017, 21: 274-283.e5. PMID: 28736217, PMCID: PMC5553280, DOI: 10.1016/j.stem.2017.06.017.Peer-Reviewed Original ResearchConceptsZIKV infectionNeurological complicationsZika virusZIKV-infected patientsSerious neurological complicationsZika virus infectionCortical neural progenitor cellsForebrain organoidsAdult mouse brainHigh-content chemical screenDrug candidatesNeural progenitor cellsAdult patientsHuman forebrain organoidsVirus infectionMouse modelAdult brainAdult miceMouse brainTherapeutic potentialTherapeutic treatmentInfectionProgenitor cellsBrainComplications
2016
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
Xu M, Lee E, Wen Z, Cheng Y, Huang W, Qian X, TCW J, Kouznetsova J, Ogden S, Hammack C, Jacob F, Nguyen H, Itkin M, Hanna C, Shinn P, Allen C, Michael S, Simeonov A, Huang W, Christian K, Goate A, Brennand K, Huang R, Xia M, Ming G, Zheng W, Song H, Tang H. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nature Medicine 2016, 22: 1101-1107. PMID: 27571349, PMCID: PMC5386783, DOI: 10.1038/nm.4184.Peer-Reviewed Original Research