2021
Prenatal Δ9-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation
Ellis R, Bara A, Vargas C, Frick A, Loh E, Landry J, Uzamere T, Callens J, Martin Q, Rajarajan P, Brennand K, Ramakrishnan A, Shen L, Szutorisz H, Hurd Y. Prenatal Δ9-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation. Biological Psychiatry 2021, 92: 127-138. PMID: 34895699, PMCID: PMC8957623, DOI: 10.1016/j.biopsych.2021.09.017.Peer-Reviewed Original ResearchConceptsEpigenetic dysregulationNucleus accumbensSimilar transcriptional alterationsExpression of Kmt2aComparison of RNACellular chromatinTranscriptome datasetsPrenatal THC exposureEpigenetic signaturesEpigenetic profilesAdult male offspringHuman major depressive disorderRNA sequencingTranscriptional alterationsSequencing approachPrenatal cannabis exposureMajor depressive disorderΔ9-tetrahydrocannabinol exposurePrincipal psychoactive componentMolecular signaturesUnbiased sequencing approachRat offspringUtero exposureTHC exposureCannabis exposure
2017
In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain
Chatterton Z, Hartley B, Seok M, Mendelev N, Chen S, Milekic M, Rosoklija G, Stankov A, Trencevsja-Ivanovska I, Brennand K, Ge Y, Dwork A, Haghighi F. In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. Epigenetics & Chromatin 2017, 10: 4. PMID: 28149327, PMCID: PMC5270321, DOI: 10.1186/s13072-017-0111-y.Peer-Reviewed Original ResearchMeSH KeywordsBrainDNA MethylationFemaleFetal DevelopmentFetusGestational AgeGTP-Binding Protein alpha Subunits, Gq-G11HumansImmunohistochemistryInduced Pluripotent Stem CellsMaleMaternal ExposureNeural Stem CellsNeuronsPregnancyPregnancy Trimester, SecondPromoter Regions, GeneticSmokingSuccinate DehydrogenaseTubulinConceptsMaternal smokingDorsolateral prefrontal cortexNeuronal contentCortical gray matterFetal brain growthDifferentiation of neuronsBehavioral problemsFalse discovery correctionSignificant DMRsSmoking exposureGestational ageSecond trimesterUtero exposurePrenatal exposureCortical developmentFetal brainExposure altersSmokingBrain growthGray matterCell proportionFetusesPrefrontal cortexDNA methylationMethylation profiles