2023
Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings
Hicks E, Seah C, Cote A, Marchese S, Brennand K, Nestler E, Girgenti M, Huckins L. Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings. Translational Psychiatry 2023, 13: 129. PMID: 37076454, PMCID: PMC10115809, DOI: 10.1038/s41398-023-02412-7.Peer-Reviewed Original ResearchConceptsBioinformatics approachTranscriptomic dataBrain transcriptomeGenome-wide analysisDynamic transcriptional landscapeBrain gene expression dataGene expression dataTranscriptional landscapeTranscriptomic studiesIntegrating GeneticExpression dataPhenotypic signaturesGenomic driversTranscriptomeMajor depressive disorderValuable resourceRecent findingsEnvironmental influencesTranscriptomicsDepressive disorderGeneticsMultiple approachesPathophysiology of depressionSignaturesDysregulation
2022
Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection
Singh K, Martinez M, Lin J, Gregory J, Nguyen T, Abdelaal R, Kang K, Brennand K, Grünweller A, Ouyang Z, Phatnani H, Kielian M, Wendel H. Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection. Viruses 2022, 14: 1418. PMID: 35891396, PMCID: PMC9316442, DOI: 10.3390/v14071418.Peer-Reviewed Original ResearchConceptsAminoacyl-tRNA synthetasesHuman neuronal progenitor cellsUpstream ORFsStress responseCellular stress responseOpen reading frameCell stress responseSimultaneous RNA sequencingViral RNA genomeGene expression dataNeuronal progenitor cellsZika virusRibosome occupancyDengue virusGenome sequenceTRNA synthetasesReading frameRNA sequencingRNA translationRNA genomeTranslation capacityKey enzymeViral translationExpression dataRNA viruses