2020
Differential Transcriptional Responses to Glucocorticoid Activation in Cultured Blood Immune Cells and Neurons: A Novel Approach to PTSD Biomarker Development
Breen M, Bierer L, Bader H, Makotkine I, Flory J, Meaney M, Brennand K, Yehuda R. Differential Transcriptional Responses to Glucocorticoid Activation in Cultured Blood Immune Cells and Neurons: A Novel Approach to PTSD Biomarker Development. Biological Psychiatry 2020, 87: s49-s50. DOI: 10.1016/j.biopsych.2020.02.151.Peer-Reviewed Original ResearchBlood immune cellsImmune cellsGlucocorticoid activationBiomarker developmentDifferential transcriptional responsesNeuronsTranscriptional responseCorrection: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development
Breen M, Bierer L, Daskalakis N, Bader H, Makotkine I, Chattopadhyay M, Xu C, Grice A, Tocheva A, Flory J, Buxbaum J, Meaney M, Brennand K, Yehuda R. Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Translational Psychiatry 2020, 10: 1. PMID: 32066695, PMCID: PMC7026151, DOI: 10.1038/s41398-019-0665-5.Peer-Reviewed Original ResearchBlood immune cellsImmune cellsGlucocorticoid activationBiomarker developmentDifferential transcriptional responsesTranscriptional response
2019
Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development
Breen MS, Bierer LM, Daskalakis NP, Bader HN, Makotkine I, Chattopadhyay M, Xu C, Buxbaum Grice A, Tocheva AS, Flory JD, Buxbaum JD, Meaney MJ, Brennand K, Yehuda R. Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Translational Psychiatry 2019, 9: 201. PMID: 31434874, PMCID: PMC6704073, DOI: 10.1038/s41398-019-0539-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersConstitutive Androstane ReceptorDexamethasoneDose-Response Relationship, DrugGene ExpressionGene Expression ProfilingGene Regulatory NetworksGlucocorticoidsHumansLeukocytes, MononuclearMaleMiddle AgedStress Disorders, Post-TraumaticTranscription, GeneticVeteransYoung AdultConceptsPeripheral blood mononuclear cellsPost-traumatic stress disorderGlucocorticoid signalingCultured peripheral blood mononuclear cellsBlood immune cellsBlood mononuclear cellsTranscriptional responseConcentrations of dexamethasoneDifferential transcriptional changesGenome-wide gene expression profilingCombat-exposed veteransStress-responsive pathwaysMolecular responseClinical manifestationsInflammatory cytokinesDynamic transcriptional responseMononuclear cellsApoptosis-related pathwaysImmune cellsBaseline differencesDifferential transcriptional responsesDifferential molecular responsesGlucocorticoid stimulationNovel markerReliable marker