2021
Transcriptional Perturbations to Glucocorticoids Across Blood and Brain Cells Derived From Individuals With Post-Traumatic Stress Disorder
Breen M, Bierer L, Bader H, Xu C, Flory J, Rusielewicz T, Brennand K, Yehuda R. Transcriptional Perturbations to Glucocorticoids Across Blood and Brain Cells Derived From Individuals With Post-Traumatic Stress Disorder. Biological Psychiatry 2021, 89: s18-s19. DOI: 10.1016/j.biopsych.2021.02.066.Peer-Reviewed Original Research In Press
2020
Pluripotent Stem Cells May Unlock How Genetic Variants Result in Mental Disorders
Powell S, Yu A, Katz C, Brennand K. Pluripotent Stem Cells May Unlock How Genetic Variants Result in Mental Disorders. Psychiatric News 2020, 55 DOI: 10.1176/appi.pn.2020.7b14.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2014
Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders
Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders. Neuron 2014, 82: 560-572. PMID: 24726381, PMCID: PMC4051437, DOI: 10.1016/j.neuron.2014.03.002.Peer-Reviewed Original ResearchConceptsCerebral cortical cellsHuman neural progenitor cellsNeural progenitor cellsHeat shock factor 1Maternal seizuresSeizure susceptibilityPrenatal exposureNeuropsychiatric dysfunctionShock factor 1Neuronal responsesBrain cellsSchizophrenia patientsBrain disordersLate onsetMouse cortexStructural abnormalitiesNeuropsychiatric disordersHSF1 deficiencyExposure of embryosProgenitor cellsSubthreshold levelsFactor 1Induced pluripotent stem cellsEnvironmental insultsCortical cells