2020
Cell-Penetrable Peptide-Conjugated FADD Induces Apoptosis and Regulates Inflammatory Signaling in Cancer Cells
Ranjan K, Waghela BN, Vaidya FU, Pathak C. Cell-Penetrable Peptide-Conjugated FADD Induces Apoptosis and Regulates Inflammatory Signaling in Cancer Cells. International Journal Of Molecular Sciences 2020, 21: 6890. PMID: 32961826, PMCID: PMC7555701, DOI: 10.3390/ijms21186890.Peer-Reviewed Original ResearchConceptsFADD proteinCancer cellsAnti-apoptotic genesCaveolar pathwayDeath domainCellular pathwaysCancer cell proliferationCytosolic expressionFADD expressionCell deathApoptosis inducersInduces ApoptosisExpression of FasProteinCell proliferationApoptosisNF-κB activationSimultaneous regulationInflammatory signalingExpressionCellsNLRP3 inflammasome primingRegulationPathwayInflammasome priming
2016
Expression of FADD and cFLIPL balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death
Ranjan K, Pathak C. Expression of FADD and cFLIPL balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death. Molecular And Cellular Biochemistry 2016, 422: 135-150. PMID: 27619661, DOI: 10.1007/s11010-016-2813-z.Peer-Reviewed Original ResearchConceptsExpression of FADDMitochondrial integrityCell deathDeath receptorsMutant of FADDInduced expressionNon-apoptotic functionsDeath receptor signalingFate of cellsMitochondrial-associated apoptosisApoptotic cell deathCancer cellsCellular signalingEctopic expressionJNK1 activationFADDCellular respirationHA14-1Independent pathwaysReceptor signalingCFLIPCFLIPLBcl-2ApoptosisIntracellular ROS
2013
Regulation of HA14‐1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells
Ranjan K, Sharma A, Surolia A, Pathak C. Regulation of HA14‐1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells. BioFactors 2013, 40: 157-169. PMID: 23559532, DOI: 10.1002/biof.1098.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisAutophagyBenzopyransCaspase 3CatalaseCell ProliferationCell SurvivalCurcuminDrug Resistance, NeoplasmDrug SynergismHEK293 CellsHumansMembrane Potential, MitochondrialNitrilesOxidative StressProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesSuperoxide DismutaseTranscription Factor RelAConceptsHuman embryonic kidney cellsHA14-1Embryonic kidney cellsProcess of autophagyHEK 293T cellsOxidative stressAntiapoptotic protein Bcl-2Kidney cellsProtein Bcl-2Toxic responsePromotion of malignancyAugmentation of apoptosisGeneration of ROSSignaling mechanismAntiapoptotic proteinsCell deathCancerous cell linesApoptotic activityCell proliferationBcl-2Cell linesPathological consequencesROS generationApoptosisROS
2012
Apoptotic potential of Fas‐associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells
Ranjan K, Surolia A, Pathak C. Apoptotic potential of Fas‐associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells. Journal Of Cell Communication And Signaling 2012, 6: 155-168. PMID: 22791313, PMCID: PMC3421020, DOI: 10.1007/s12079-012-0166-2.Peer-Reviewed Original ResearchFas-associated death domainHEK 293T cellsDeath effector domainDeath receptorsDeath domainProcaspase-8Anti-apoptotic protein cFLIPExecution of apoptosisFADD protein expressionCommon adaptor moleculeAnti-apoptotic proteinsDED motifsInduction of apoptosisEffector domainExtrinsic caspaseInhibition of apoptosisElevated intracellular levelsAdaptor moleculeCell survivalCFLIPApoptotic potentialApoptosisCell proliferationElevated expressionIntracellular levels