2024
Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis
Ilagan-Ying Y, Gordon K, Tate J, Lim J, Torgersen J, Re V, Justice A, Taddei T. Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis. JAMA Network Open 2024, 7: e2443608. PMID: 39504020, PMCID: PMC11541635, DOI: 10.1001/jamanetworkopen.2024.43608.Peer-Reviewed Original ResearchConceptsClassification of DiseasesBody mass indexRisk scoreNinth Revision and International Statistical Classification of DiseasesMass indexAlcohol useInternational Statistical Classification of DiseasesStatistical Classification of DiseasesElectronic health recordsNon-Hispanic blacksInternational Classification of DiseasesNon-Hispanic whitesClinical Modification diagnosisHepatocellular carcinoma risk scoreRisk of hepatocellular carcinomaCox proportional hazards regression modelsValidation sampleHigh-risk individualsProportional hazards regression modelsHCC risk factorsFIB-4Multivariate risk scoreHepatocellular carcinomaHazards regression modelsViral hepatitisPain, Substance Use Disorders, Mental Health, and Buprenorphine Treatment among Patients With and Without HIV
Miller E, McGinnis K, Edelman E, Feinberg T, Gordon K, Kerns R, Marshall B, Patterson J, McRae M. Pain, Substance Use Disorders, Mental Health, and Buprenorphine Treatment among Patients With and Without HIV. AIDS And Behavior 2024, 1-11. PMID: 39264485, DOI: 10.1007/s10461-024-04494-w.Peer-Reviewed Original ResearchMental health classesSubstance use disordersOpioid use disorderHIV statusBuprenorphine initiationVeterans Aging Cohort StudyInitiate buprenorphineMental health diagnosesAging Cohort StudyBuprenorphine treatmentMultiple pain conditionsAssociated with HIV statusInfluence treatment retentionUse disorderTreatment of opioid use disorderHigher comorbidity burdenAge of patientsClinical encountersMental healthHealth diagnosisBlack veteransHealth classesLatent class analysisCohort studyPrescription dataMedications for alcohol‐use disorder and follow‐up after hospitalization for alcohol withdrawal: A multicenter study
Allaudeen N, Akwe J, Arundel C, Boggan J, Caldwell P, Cornia P, Cyr J, Ehlers E, Elzweig J, Godwin P, Gordon K, Guidry M, Gutierrez J, Heppe D, Hoegh M, Jagannath A, Kaboli P, Krug M, Laudate J, Mitchell C, Pescetto M, Rodwin B, Ronan M, Rose R, Shah M, Smeraglio A, Trubitt M, Tuck M, Vargas J, Yarbrough P, Gunderson C. Medications for alcohol‐use disorder and follow‐up after hospitalization for alcohol withdrawal: A multicenter study. Journal Of Hospital Medicine 2024 PMID: 39031461, DOI: 10.1002/jhm.13458.Peer-Reviewed Original ResearchAlcohol-use disordersResidential treatment programAlcohol withdrawalFollow-up appointmentsImprove abstinenceAll-cause 30-day readmissionFollow-upTreatment programsReturn to heavy drinkingAssociated with improved outcomesRetrospective cohort studyOutpatient follow-upEffects of medicationAssociated with readmissionTime of dischargeVeterans Health Administration hospitalsAssociated with decreased readmissionMulticenter studyAcute care hospitalsAssociated with reduced 30-day readmissionsResidential programsPrescription of medicationsAbstinenceCohort studyHeavy drinkingContribution of Potentially Inappropriate Medications to Polypharmacy-Associated Risk of Mortality in Middle-Aged Patients: A National Cohort Study
Guillot J, Justice A, Gordon K, Skanderson M, Pariente A, Bezin J, Rentsch C. Contribution of Potentially Inappropriate Medications to Polypharmacy-Associated Risk of Mortality in Middle-Aged Patients: A National Cohort Study. Journal Of General Internal Medicine 2024, 1-10. PMID: 38831248, DOI: 10.1007/s11606-024-08817-4.Peer-Reviewed Original ResearchMiddle-aged patientsRisk of mortalityVeterans AffairsChronic medicationsVA patient populationIntegrated healthcare systemNational cohort studyAssociated with increased mortalityMiddle-aged individualsMechanism of injuryMiddle-aged peopleAssociated with mortalityInappropriate medicationsBeers criteriaHealthcare systemAttenuate riskCohort studyClinical characteristicsGeneral populationHyperpolypharmacyFollow-upPolypharmacyPatient populationBackgroundThe roleCox modelPatterns of gabapentin prescription and of hospitalization in a national cohort of US Veterans
Levy D, Gordon K, Bastian L, Brandt C, Gunderson C. Patterns of gabapentin prescription and of hospitalization in a national cohort of US Veterans. Pain Medicine 2024, 25: 534-537. PMID: 38676664, DOI: 10.1093/pm/pnae027.Peer-Reviewed Original ResearchContemporary Management and Outcomes of Veterans Hospitalized With Alcohol Withdrawal: A Multicenter Retrospective Cohort Study
Ronan M, Gordon K, Skanderson M, Krug M, Godwin P, Heppe D, Hoegh M, Boggan J, Gutierrez J, Kaboli P, Pescetto M, Guidry M, Caldwell P, Mitchell C, Ehlers E, Allaudeen N, Cyr J, Smeraglio A, Yarbrough P, Rose R, Jagannath A, Vargas J, Cornia P, Shah M, Tuck M, Arundel C, Laudate J, Elzweig J, Rodwin B, Akwe J, Trubitt M, Gunderson C. Contemporary Management and Outcomes of Veterans Hospitalized With Alcohol Withdrawal: A Multicenter Retrospective Cohort Study. Journal Of Addiction Medicine 2024, 18: 389-396. PMID: 38452185, DOI: 10.1097/adm.0000000000001297.Peer-Reviewed Original ResearchSymptom-triggered therapyRetrospective cohort studyTreatment durationComplicated withdrawalVeterans Health AdministrationAlcohol withdrawalFixed doseFactors associated with treatment durationCohort studyMulticenter retrospective cohort studyFixed-dose regimensLong-acting benzodiazepinesVeterans Health Administration Corporate Data WarehouseShort-acting benzodiazepineAmerican Society of Addiction Medicine (ASAMAlcohol withdrawal managementChart reviewHealth care systemCorporate Data WarehouseOutcomes of veteransInpatient managementTherapyWithdrawal managementHospital outcomesManagement pathway
2023
The Association of Prescribed Opioids and Incident Cardiovascular Disease
Sung M, Eden S, Becker W, Crystal S, Duncan M, Gordon K, Kerns R, Kundu S, Freiberg M, So-Armah K, Edelman E. The Association of Prescribed Opioids and Incident Cardiovascular Disease. Journal Of Pain 2023, 25: 104436. PMID: 38029949, PMCID: PMC11058015, DOI: 10.1016/j.jpain.2023.11.019.Peer-Reviewed Original ResearchIncident cardiovascular diseaseModifiable CVD risk factorsCVD risk factorsHuman immunodeficiency virusCardiovascular diseasePrescribed opioidsOpioid receiptRisk factorsUse disordersCox proportional hazards regression modelVeterans Aging Cohort StudyVeterans Health Administration (VHA) carePropensity scoreProportional hazards regression modelsCVD incidence ratesPrescription opioid exposureIncident CVD eventsPrevalence of hypertensionAging Cohort StudyHigher opioid dosesOpioid use disorderHazards regression modelsNational prospective cohortVeterans Administration dataCocaine use disorderOpioid prescription and risk of atrial fibrillation in younger veterans
Chui P, Khokhar A, Gordon K, Dziura J, Burg M, Brandt C, Haskell S, Malm B, Bastian L, Gandhi P. Opioid prescription and risk of atrial fibrillation in younger veterans. American Heart Journal 2023, 268: 61-67. PMID: 37949420, DOI: 10.1016/j.ahj.2023.11.001.Peer-Reviewed Original ResearchTime-updated Cox regressionIncident atrial fibrillationAtrial fibrillationOpioid exposureVeterans Health AdministrationOpioid typeCox regressionOpioid prescriptionsICD-9-CM diagnostic codesIncidence of AFDevelopment of AFPrescription opioid exposureModifiable risk factorsPrimary care visitsPrescribed opioidsCare visitsOpioid useRisk factorsDiagnostic codesTime-dependent variablesOpioidsHealth AdministrationYounger veteransBaseline periodStudy sampleRelationship Between Pain and LGBT Status Among Veterans in Care in a Retrospective Cross-Sectional Cohort
Gordon K, Buta E, Pratt-Chapman M, Brandt C, Gueorguieva R, Warren A, Workman T, Zeng-Treitler Q, Goulet J. Relationship Between Pain and LGBT Status Among Veterans in Care in a Retrospective Cross-Sectional Cohort. Journal Of Pain Research 2023, 16: 4037-4047. PMID: 38054108, PMCID: PMC10695019, DOI: 10.2147/jpr.s432967.Peer-Reviewed Original ResearchRetrospective cross-sectional cohortCross-sectional cohortPersistent painSelf-reported pain scoresVeterans Health AdministrationRobust Poisson modelsCorporate Data WarehouseLGBT veteransPain screeningPain scoresClinic visitsPain assessmentPainAdjusted modelHealth AdministrationGreater painMental healthSubstance useCohortYear of entryBlack veteransHealthcare systemVeteransSignificant differencesAdministrative dataGraded chronic pain scale revised: validation in a Veteran sample
Taub C, Gordon K, Goulet J, Lee A, Mayhew M, Von Korff M, DeBar L, Kerns R. Graded chronic pain scale revised: validation in a Veteran sample. Pain Medicine 2023, 24: 1169-1175. PMID: 37220899, PMCID: PMC10546477, DOI: 10.1093/pm/pnad068.Peer-Reviewed Original ResearchConceptsGraded Chronic Pain ScaleHigh-impact chronic painAdjusted odds ratioMild chronic painChronic Pain ScaleChronic painPain scaleConfidence intervalsLong-term opioid therapyHigh-risk populationOpioid therapyPain gradeUS veteransOdds ratioActivity limitationsPainPain researchLogistic regressionVeteran sampleHealth indicatorsStudy objectiveConvergent validityValidation studyVeteransPsychological variablesEstimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis
Carey G, Holleck J, Alshaeba S, Jayakrishnan R, Gordon K, Grimshaw A, Gunderson C. Estimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis. Journal Of Antimicrobial Chemotherapy 2023, 78: 1150-1159. PMID: 36964648, DOI: 10.1093/jac/dkad078.Peer-Reviewed Original ResearchConceptsCommon infectious syndromesEmpirical antibioticsPrevalence of MRSAInfectious syndromesMRSA infectionIll patientsMortality rateSystematic reviewAbsolute mortality benefitAnti-MRSA therapyEmpirical antibiotic coverageLow-risk infectionsSoft tissue infectionsUrinary tract infectionAbsolute risk reductionMethicillin-resistant Staphylococcus aureusCatheter-related infectionsStudy of patientsBaseline mortality ratesSystematic literature searchWeb of ScienceMRSA coverageAntibiotic coverageEmpirical antimicrobialsMortality benefitHuman Immunodeficiency Virus Status, Tenofovir Exposure, and the Risk of Poor Coronavirus Disease 19 Outcomes: Real-World Analysis From 6 United States Cohorts Before Vaccine Rollout
Lea A, Leyden W, Sofrygin O, Marafino B, Skarbinski J, Napravnik S, Agil D, Augenbraun M, Benning L, Horberg M, Jefferson C, Marconi V, Park L, Gordon K, Bastarache L, Gangireddy S, Althoff K, Coburn S, Gebo K, Lang R, Williams C, Silverberg M. Human Immunodeficiency Virus Status, Tenofovir Exposure, and the Risk of Poor Coronavirus Disease 19 Outcomes: Real-World Analysis From 6 United States Cohorts Before Vaccine Rollout. Clinical Infectious Diseases 2023, 76: 1727-1734. PMID: 36861341, PMCID: PMC10209434, DOI: 10.1093/cid/ciad084.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAdjusted risk ratioCOVID-19 hospitalizationMechanical ventilationTenofovir useHIV statusAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSevere coronavirus disease 2019 (COVID-19) outcomesSyndrome coronavirus 2 infectionCoronavirus disease 2019 (COVID-19) outcomesHuman immunodeficiency virus statusCohort of PWHCD4 cell countCharlson Comorbidity IndexCoronavirus 2 infectionHIV RNA levelsUnited States cohortBody mass indexCOVID-19 severityCOVID-19 vaccine availabilityReal-world analysisTenofovir exposureComorbidity indexMass indexVariation in firearm screening and access by LGBT status
Goulet J, Warren A, Workman T, Skanderson M, Farmer M, Gordon K, Abel E, Akgün K, Bean‐Mayberry B, Zeng‐Treitler Q, Haderlein T, Haskell S, Bastian L, Womack J, Post L, Hwang U, Brandt C. Variation in firearm screening and access by LGBT status. Academic Emergency Medicine 2023, 30: 420-423. PMID: 36661348, DOI: 10.1111/acem.14664.Peer-Reviewed Original ResearchDelirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications
Akgün K, Krishnan S, Tate J, Bryant K, Pisani M, Re V, Rentsch C, Crothers K, Gordon K, Justice A, team F. Delirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications. Journal Of The American Geriatrics Society 2023, 71: 1861-1872. PMID: 36786300, PMCID: PMC10258127, DOI: 10.1111/jgs.18265.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification Test-ConsumptionActive medicationAlcohol useOdds ratioRelative riskDose-response associationDate of admissionSeverity of illnessIndependent dose-response associationsRace/ethnicityInpatient deliriumIndex dateMedication exposureRole of alcoholHIV statusMultivariable analysisMedication countNeurocognitive dysfunctionUnderappreciated causeDeliriumHigh incidencePWHMedicationsPWOHLogistic regressionEnhanced Identification of Hispanic Ethnicity Using Clinical Data
Ochoa-Allemant P, Tate J, Williams E, Gordon K, Marconi V, Bensley K, Rentsch C, Wang K, Taddei T, Justice A, Cohorts F. Enhanced Identification of Hispanic Ethnicity Using Clinical Data. Medical Care 2023, 61: 200-205. PMID: 36893404, PMCID: PMC10114212, DOI: 10.1097/mlr.0000000000001824.Peer-Reviewed Original ResearchConceptsBurden of diseaseHispanic patientsCountry of birthClinical dataHispanic ethnicityNon-Hispanic white patientsSex-adjusted prevalenceChronic liver diseaseHuman immunodeficiency virusDemographic characteristicsElectronic health record dataHealth careHealth record dataPrevalence of conditionsUS health care systemMedicare administrative dataHealth care systemWhite patientsLiver diseaseImmunodeficiency virusSelf-reported ethnicityHigh prevalenceGastric cancerHepatocellular carcinomaVeteran populationWhat internal medicine attendings talk about at morning report: a multicenter study
Redinger J, Heppe D, Albert T, Cornia P, Gordon K, Arundel C, Bradley J, Caputo L, Chun J, Cyr J, Ehlers E, Guidry M, Jagannath A, Kwan B, Laudate J, Mitchell C, Smeraglio A, Sweigart J, Tuck M, Gunderson C. What internal medicine attendings talk about at morning report: a multicenter study. BMC Medical Education 2023, 23: 84. PMID: 36732763, PMCID: PMC9893973, DOI: 10.1186/s12909-023-04057-y.Peer-Reviewed Original ResearchFactors Associated with Bothersome Symptoms in Individuals With and Without HIV Who Report Alcohol Use
Bahji A, Gordon K, Crystal S, Satre D, Wiliams E, Edelman E, Justice A. Factors Associated with Bothersome Symptoms in Individuals With and Without HIV Who Report Alcohol Use. AIDS And Behavior 2023, 27: 2455-2462. PMID: 36622487, PMCID: PMC10225332, DOI: 10.1007/s10461-022-03972-3.Peer-Reviewed Original Research
2022
1265. Effectiveness and Durability of Dolutegravir (DTG)-Based Regimens in Older People Living with HIV (PLWH) from the Veterans Aging Cohort Study (VACS)
Yan L, Henegar C, Gordon K, Hicks C, Vannappagari V, Justice A, Aslan M. 1265. Effectiveness and Durability of Dolutegravir (DTG)-Based Regimens in Older People Living with HIV (PLWH) from the Veterans Aging Cohort Study (VACS). Open Forum Infectious Diseases 2022, 9: ofac492.1096. PMCID: PMC9752102, DOI: 10.1093/ofid/ofac492.1096.Peer-Reviewed Original ResearchVeterans Aging Cohort StudyDTG-based regimensAging Cohort StudyViiV HealthcareCohort studyOlder peopleART-experienced individualsCD4 cell countEnd of studyRegimen discontinuationRegimen initiationAntiretroviral regimensVirologic failureART-naïveMultiple comorbiditiesHIV managementOlder PLWHPLWHTreatment responseTreatment statusRegimensTreatment experienceDolutegravirRaltegravirCell countTemporal and Geographic Patterns of Documentation of Sexual Orientation and Gender Identity Keywords in Clinical Notes
Workman T, Goulet J, Brandt C, Lindemann L, Skanderson M, Warren A, Eleazer J, Kronk C, Gordon K, Pratt-Chapman M, Zeng-Treitler Q. Temporal and Geographic Patterns of Documentation of Sexual Orientation and Gender Identity Keywords in Clinical Notes. Medical Care 2022, 61: 130-136. PMID: 36511399, PMCID: PMC9931630, DOI: 10.1097/mlr.0000000000001803.Peer-Reviewed Original ResearchDifferences in COVID-19 testing and adverse outcomes by race, ethnicity, sex, and health system setting in a large diverse US cohort
Jefferson C, Watson E, Certa J, Gordon K, Park L, D’Souza G, Benning L, Abraham A, Agil D, Napravnik S, Silverberg M, Leyden W, Skarbinski J, Williams C, Althoff K, Horberg M, Team O. Differences in COVID-19 testing and adverse outcomes by race, ethnicity, sex, and health system setting in a large diverse US cohort. PLOS ONE 2022, 17: e0276742. PMID: 36417366, PMCID: PMC9683575, DOI: 10.1371/journal.pone.0276742.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 testingRace/ethnicityRelative risk ratiosAdverse outcomesCOVID-19 testingHealth system typesWhite patientsBlack patientsUS cohortCOVID-19-related hospitalizationAsian/Pacific Islander patientsDiverse US cohortPacific Islander patientsLow positivity rateCOVID-19 pandemicEvidence of disparitiesElectronic health recordsCohort CollaborationHispanic patientsPatient reportingPrimary exposureRisk ratioRisk factorsPositivity rateHigh burden