2023
The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia.
Bager L, Petersen J, Havers-Borgersen E, Resch T, Smolderen K, Mena-Hurtado C, Eiberg J, Køber L, Fosbøl E. The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia. European Journal Of Preventive Cardiology 2023, 30: 1092-1100. PMID: 36708037, DOI: 10.1093/eurjpc/zwad022.Peer-Reviewed Original ResearchConceptsEvidence-based medical therapyARB/ACEILimb-threatening ischaemiaMyocardial infarctionMedical therapyHistory of MIHigh-risk patientsFirst-time hospitalizationUnadjusted odds ratioYears of ageMore comorbiditiesPatients 40Hazard ratioDanish registriesOverall mortalityAdjusted analysisAdverse prognosisOdds ratioPractice patternsPatientsMortality rateACEIIschaemiaTherapyMortality
2022
Derivation and validation of a predictive model for chronic stress in patients with cardiovascular disease
Malik AO, Jones PG, Mena-Hurtado C, Burg MM, Shishehbor MH, Hejjaji V, Tran A, Spertus JA, Smolderen KG. Derivation and validation of a predictive model for chronic stress in patients with cardiovascular disease. PLOS ONE 2022, 17: e0275729. PMID: 36256655, PMCID: PMC9578618, DOI: 10.1371/journal.pone.0275729.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCohort StudiesFemaleHumansMaleMiddle AgedMyocardial InfarctionPeripheral Arterial DiseaseRegistriesRisk FactorsConceptsPeripheral artery diseaseCardiovascular diseaseChronic stressWorse outcomesSymptomatic peripheral artery diseaseMyocardial Infarction RegistryLogistic regression modelsPAD patientsProspective registryCurrent smokingArtery diseaseClinical factorsDerivation cohortValidation cohortC-statisticFemale sexPerceived Stress ScalePatientsEconomic burdenMedical careInstrument scoresSocioeconomic statusPotential targetDiseasePSS-4 scores
2021
Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry
Smolderen KG, Lee M, Arora T, Simonov M, Mena-Hurtado C. Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry. Current Problems In Cardiology 2021, 47: 101007. PMID: 34627824, PMCID: PMC8496926, DOI: 10.1016/j.cpcardiol.2021.101007.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCOVID-19FemaleHumansMaleMiddle AgedMyocardial InfarctionPeripheral Arterial DiseaseRegistriesRisk FactorsSARS-CoV-2StrokeConceptsPeripheral arterial diseaseSARS-CoV-2Myocardial infarctionMajor adverse cardiovascular eventsAdverse cardiovascular eventsPeripheral artery diseaseOdds of mortalityCOVID-19 infectionCOVID-19 outcomesLogistic regression modelsCardiovascular eventsArtery diseaseArterial diseaseMean ageRisk factorsWorse outcomesPatientsMinority raceMortalityRegistryStrokeDiseaseMACERegression modelsOutcomes
2019
Psychosocial Factors and Recovery After Acute Myocardial Infarction in Younger Women
Smolderen KG, Brush A, Dreyer RP. Psychosocial Factors and Recovery After Acute Myocardial Infarction in Younger Women. Current Cardiology Reports 2019, 21: 50. PMID: 31020453, DOI: 10.1007/s11886-019-1140-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleHumansIncidenceMiddle AgedMyocardial InfarctionPsychologyRisk FactorsSex FactorsSocioeconomic FactorsYoung AdultConceptsYoung womenAMI outcomesAMI carePsychosocial factorsPsychosocial stressorsAcute myocardial infarction riskAcute myocardial infarctionMyocardial infarction riskPurpose of ReviewToPotential psychosocial factorsAMI riskMyocardial infarctionCare pathwayOutpatient careWorse outcomesAMI incidenceInfarction riskEquitable careMortality ratePsychosocial interventionsCareWomenOutcomesRiskIncidence
2018
Depression and long-term prognostic outcomes following peripheral endovascular interventions in the VA Healthcare System
Smolderen KG, Plomondon ME, Armstrong EJ, Hess E, Waldo S, Tsai TT, Maddox TM. Depression and long-term prognostic outcomes following peripheral endovascular interventions in the VA Healthcare System. Vascular Medicine 2018, 23: 454-460. PMID: 29801427, DOI: 10.1177/1358863x18770275.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedChi-Square DistributionComorbidityDepressionEndovascular ProceduresFemaleHumansHypertensionKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPeripheral Arterial DiseaseProportional Hazards ModelsRetrospective StudiesRisk FactorsStrokeTime FactorsTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsNon-fatal cardiovascular eventsPeripheral vascular interventionsCardiovascular eventsDiagnosis of depressionHazard ratioMedical recordsAge-adjusted hazard ratioLong-term prognostic outcomesNon-fatal cardiovascular outcomesPeripheral endovascular interventionsLong-term outcomesPatients' medical recordsVA healthcare systemVeterans Affairs centersCause deathCardiovascular outcomesConsecutive patientsAdditional covariatesEndovascular interventionRecent diagnosisPrognostic outcomesDepressed patientsDisease outcomeVascular interventionsHigh risk
2017
Prognostic Impact of Subsequent Acute Coronary Syndrome and Unplanned Revascularization on Long‐Term Mortality After an Index Percutaneous Coronary Intervention: A Report From a Japanese Multicenter Registry
Inohara T, Kohsaka S, Miyata H, Sawano M, Ueda I, Maekawa Y, Fukuda K, Jones PG, Cohen DJ, Zhao Z, Spertus JA, Smolderen KG. Prognostic Impact of Subsequent Acute Coronary Syndrome and Unplanned Revascularization on Long‐Term Mortality After an Index Percutaneous Coronary Intervention: A Report From a Japanese Multicenter Registry. Journal Of The American Heart Association 2017, 6: e006529. PMID: 29079567, PMCID: PMC5721753, DOI: 10.1161/jaha.117.006529.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableChi-Square DistributionFemaleHospitals, TeachingHumansIncidenceJapanLogistic ModelsMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPropensity ScoreProportional Hazards ModelsRegistriesRetreatmentRisk FactorsTime FactorsTreatment OutcomeConceptsSubsequent acute coronary syndromeAcute coronary syndromePercutaneous coronary interventionPropensity-matched cohortUnplanned coronary revascularizationIndex percutaneous coronary interventionComposite end pointUnplanned revascularizationCoronary revascularizationCoronary syndromeCoronary interventionUnstable anginaClinical trialsEnd pointJapanese multicenter registryLong-term mortalityAcute myocardial infarctionRisk of mortalityProportional hazards modelLong-term survivalJapanese teaching hospitalsCause mortalityMulticenter registryPCI patientsSubsequent survivalResponse by Smolderen et al to Letter Regarding Article, “Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction
Smolderen KGE, Gosch KG, Buchanan DM, Spertus JA. Response by Smolderen et al to Letter Regarding Article, “Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction. Circulation 2017, 136: 1355-1356. PMID: 28972066, PMCID: PMC9901181, DOI: 10.1161/circulationaha.117.030175.Peer-Reviewed Original ResearchMeSH KeywordsDepressionHealth StatusHumansMyocardial InfarctionRegistriesTranslational Research, BiomedicalDepression Treatment and Health Status Outcomes in Young Patients With Acute Myocardial Infarction
Smolderen KG, Spertus JA, Gosch K, Dreyer RP, D'Onofrio G, Lichtman JH, Geda M, Beltrame J, Safdar B, Bueno H, Krumholz HM. Depression Treatment and Health Status Outcomes in Young Patients With Acute Myocardial Infarction. Circulation 2017, 135: 1762-1764. PMID: 28461419, PMCID: PMC5755692, DOI: 10.1161/circulationaha.116.027042.Peer-Reviewed Original ResearchDepression Treatment and 1-Year Mortality After Acute Myocardial Infarction
Smolderen KG, Buchanan DM, Gosch K, Whooley M, Chan PS, Vaccarino V, Parashar S, Shah AJ, Ho PM, Spertus JA. Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction. Circulation 2017, 135: 1681-1689. PMID: 28209727, PMCID: PMC5796757, DOI: 10.1161/circulationaha.116.025140.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntidepressive AgentsCause of DeathDepressionFemaleHealth StatusHumansKaplan-Meier EstimateMaleMental HealthMiddle AgedMyocardial InfarctionProportional Hazards ModelsProspective StudiesPsychiatric Status Rating ScalesQuality of LifeRegistriesRisk AssessmentRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionPatient Health Questionnaire-9Untreated depressionMyocardial infarctionObservational multicenter cohort studyMulticenter cohort studyOne-year mortalityLong-term mortalityPrognosis of patientsPHQ-9 scoresTreatment of depressionPHQ-9 criteriaAMI severityPHQ scoresTRIUMPH studyCohort studyClinical factorsDepression treatmentDischarge diagnosisQuestionnaire-9Medical recordsAMI admissionsPatientsBetter outcomesMortality rateSex Differences in 1-Year All-Cause Rehospitalization in Patients After Acute Myocardial Infarction
Dreyer RP, Dharmarajan K, Kennedy KF, Jones PG, Vaccarino V, Murugiah K, Nuti SV, Smolderen KG, Buchanan DM, Spertus JA, Krumholz HM. Sex Differences in 1-Year All-Cause Rehospitalization in Patients After Acute Myocardial Infarction. Circulation 2017, 135: 521-531. PMID: 28153989, PMCID: PMC5312975, DOI: 10.1161/circulationaha.116.024993.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseFemaleHumansMaleMiddle AgedMyocardial InfarctionPatient ReadmissionProspective StudiesSex FactorsConceptsAcute myocardial infarctionAge-sex interactionHigh riskRehospitalization ratesClinical factorsMyocardial infarctionCox proportional hazards modelSignificant age-sex interactionCause rehospitalization rateSex differencesMedical record abstractionProportional hazards modelYears of ageFirst yearTRIUMPH studyCause rehospitalizationRecord abstractionPatient interviewsRehospitalizationUS CentersHazards modelPsychosocial factorsPhysician panelHealth statusPsychosocial state
2016
Health Status Outcomes in Patients With Acute Myocardial Infarction After Rehospitalization
Shore S, Smolderen KG, Kennedy KF, Jones PG, Arnold SV, Cohen DJ, Stolker JM, Zhao Z, Wang TY, Ho PM, Spertus JA. Health Status Outcomes in Patients With Acute Myocardial Infarction After Rehospitalization. Circulation Cardiovascular Quality And Outcomes 2016, 9: 777-784. PMID: 27780850, PMCID: PMC5794496, DOI: 10.1161/circoutcomes.116.002883.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, UnstableFemaleHealth StatusHealth Status IndicatorsHumansLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationPatient ReadmissionPredictive Value of TestsPropensity ScoreProspective StudiesQuality of LifeRegistriesRisk FactorsSurveys and QuestionnairesTime FactorsUnited StatesConceptsAcute myocardial infarctionComposite end pointUnplanned revascularizationUnstable anginaMyocardial infarctionHealth statusEuroQol-5D visual analogue scaleVisual analog scale scoreEnd pointUnplanned coronary revascularizationPropensity-matched cohortAnalog scale scoreSeattle Angina QuestionnaireVisual analog scaleHealth status outcomesWorse health statusAngina QuestionnaireCoronary revascularizationRehospitalization ratesAnalog scaleMean ageSuch readmissionsQuestionnaire domainsClinical trialsRehospitalizationClinical Relevance of Rehospitalizations for Unstable Angina and Unplanned Revascularization Following Acute Myocardial Infarction
Shore S, Smolderen KG, Spertus JA, Kennedy KF, Jones PG, Zhao Z, Wang TY, Arnold SV. Clinical Relevance of Rehospitalizations for Unstable Angina and Unplanned Revascularization Following Acute Myocardial Infarction. Journal Of The American Heart Association 2016, 5: e003129. PMID: 27543798, PMCID: PMC5015270, DOI: 10.1161/jaha.115.003129.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionUnplanned revascularizationUnstable anginaMyocardial infarctionSubsequent rehospitalizationClinical relevanceAcute Myocardial Infarction RegistryProportional hazard Cox regressionUnplanned coronary revascularizationComposite end pointMyocardial Infarction RegistryRehospitalization groupCause mortalityCoronary revascularizationRevascularization groupRehospitalization ratesPropensity matchingCox regressionMean ageClinical trialsRehospitalizationRevascularizationMortality riskHigh riskPatients
2015
Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction
Chen SI, Wang Y, Dreyer R, Strait KM, Spatz ES, Xu X, Smolderen KG, Desai NR, Lorenze NP, Lichtman JH, Spertus JA, D'Onofrio G, Bueno H, Masoudi FA, Krumholz HM. Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction. The American Journal Of Cardiology 2015, 116: 1827-1832. PMID: 26541907, PMCID: PMC5323057, DOI: 10.1016/j.amjcard.2015.09.018.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrehospital delayInsurance statusMyocardial infarctionSpanish patientsGender differencesHealth care systemUS patientsProspective studyUS cohortUS womenPatientsUniversal insuranceCare systemWomenSignificant gender differencesInfarctionMenInsurance groupsHoursStatusAssociationLarge proportionDifferencesCohortDepressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study
Smolderen KG, Strait KM, Dreyer RP, D'Onofrio G, Zhou S, Lichtman JH, Geda M, Bueno H, Beltrame J, Safdar B, Krumholz HM, Spertus JA. Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study. Journal Of The American Heart Association 2015, 4: e001424. PMID: 25836055, PMCID: PMC4579927, DOI: 10.1161/jaha.114.001424.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDepressive symptomsLifetime historyMyocardial infarctionRisk factorsYoung acute myocardial infarctionYoung AMI Patients (VIRGO) studyMore cardiovascular risk factorsYoung womenCardiovascular risk factorsTime of admissionAdverse medical outcomesMore depressive symptomsLow socioeconomic profileAMI severityVIRGO StudyCardiovascular riskChart abstractionYounger patientsClinical profileRelevant sex differencesPatient profilesAMI admissionsMedical outcomesPatientsGender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom controlRisk Factors for Rehospitalization for Acute Coronary Syndromes and Unplanned Revascularization Following Acute Myocardial Infarction
Arnold SV, Smolderen KG, Kennedy KF, Li Y, Shore S, Stolker JM, Wang TY, Jones PG, Zhao Z, Spertus JA. Risk Factors for Rehospitalization for Acute Coronary Syndromes and Unplanned Revascularization Following Acute Myocardial Infarction. Journal Of The American Heart Association 2015, 4: e001352. PMID: 25666368, PMCID: PMC4345868, DOI: 10.1161/jaha.114.001352.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeAcute myocardial infarctionCoronary syndromeMyocardial infarctionRisk factorsHospital percutaneous coronary interventionCoronary artery bypass graftSecondary prevention therapiesArtery bypass graftRisk of rehospitalizationMortality risk scorePercutaneous coronary interventionPredictors of rehospitalizationRate of rehospitalizationBare metal stentsStrongest predictorMultivessel diseaseUnplanned revascularizationCause readmissionCoronary revascularizationCoronary interventionSubsequent revascularizationPrevention therapyRevascularization proceduresAMI registry
2013
Psychological Distress and Medication Adherence
Smolderen KG, Whooley MA. Psychological Distress and Medication Adherence. Circulation Cardiovascular Quality And Outcomes 2013, 6: 615-616. PMID: 24221835, DOI: 10.1161/circoutcomes.113.000633.Peer-Reviewed Original ResearchDemographyFemaleHumansLife StyleMaleMedication AdherenceMyocardial InfarctionRacial GroupsSex Factors
2012
Perceived Stress in Myocardial Infarction Long-Term Mortality and Health Status Outcomes
Arnold SV, Smolderen KG, Buchanan DM, Li Y, Spertus JA. Perceived Stress in Myocardial Infarction Long-Term Mortality and Health Status Outcomes. Journal Of The American College Of Cardiology 2012, 60: 1756-1763. PMID: 23040574, PMCID: PMC3601381, DOI: 10.1016/j.jacc.2012.06.044.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status outcomesChronic stressHealth statusAMI patientsStatus outcomesAdverse long-term outcomesLong-term adverse outcomesEuroQol visual analogue scaleGeneric health statusPost-AMI outcomesSeattle Angina QuestionnaireLong-term mortalityShort Form-12Long-term outcomesVisual analog scaleImportant confounding factorsRecurrent adverse eventsRevascularization statusAngina QuestionnaireAdverse eventsClinical characteristicsClinical factorsForm-12Analog scale
2011
Association of Somatic and Cognitive Depressive Symptoms and Biomarkers in Acute Myocardial Infarction: Insights from the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status Registry
Smolderen KG, Spertus JA, Reid KJ, Buchanan DM, Vaccarino V, Lichtman JH, Bekelman DB, Chan PS. Association of Somatic and Cognitive Depressive Symptoms and Biomarkers in Acute Myocardial Infarction: Insights from the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status Registry. Biological Psychiatry 2011, 71: 22-29. PMID: 21903199, PMCID: PMC3332544, DOI: 10.1016/j.biopsych.2011.07.029.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedBlood PlateletsC-Reactive ProteinCognition DisordersDepressionFemaleHealth Status DisparitiesHumansLeukocyte CountMaleMiddle AgedMyocardial InfarctionNatriuretic Peptide, BrainPeptide FragmentsPrognosisRegistriesRegression AnalysisRetrospective StudiesSurveys and QuestionnairesTranslational Research, BiomedicalYoung AdultConceptsCognitive depressive symptomsSomatic depressive symptomsDepressive symptomsHs-CRPNT-proBNPWBC countAcute Myocardial Infarction Patients' Health Status (TRIUMPH) registryMyocardial infarction prognosisHs-CRP valuesLong-term outcomesAcute myocardial infarctionDepressive symptom domainsAMI prognosisIndex hospitalizationClinical characteristicsCoagulation markersAMI patientsMyocardial infarctionPlatelet levelsBiomarker levelsDepression scoresCertain biomarkersDepression dimensionSymptomsSomatic symptomsAccuracy and Prognostic Value of American Heart Association–Recommended Depression Screening in Patients With Coronary Heart Disease
Elderon L, Smolderen KG, Na B, Whooley MA. Accuracy and Prognostic Value of American Heart Association–Recommended Depression Screening in Patients With Coronary Heart Disease. Circulation Cardiovascular Quality And Outcomes 2011, 4: 533-540. PMID: 21862720, DOI: 10.1161/circoutcomes.110.960302.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationComorbidityCoronary DiseaseDepressionDepressive Disorder, MajorDiagnostic Tests, RoutineFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsPrognosisRiskSensitivity and SpecificitySurveys and QuestionnairesSurvival AnalysisUnited StatesConceptsCoronary heart diseaseAmerican Heart AssociationStable coronary heart diseasePatient Health QuestionnaireMajor depressive disorderHeart diseaseCardiovascular eventsPrognostic valueHeart AssociationDepressive disorderHealth QuestionnaireHigh-density lipoprotein levelsDepression screening protocolSubsequent cardiovascular eventsAdverse cardiovascular outcomesBody mass indexGold standard interviewCardiovascular outcomesIdentifies patientsHeart failureScreening methodLipoprotein levelsMass indexDepression screeningMyocardial infarction