2022
Risk profiles, access to care, and outcomes in Hispanics hospitalized for lower extremity peripheral artery disease
Luna P, Harris K, Castro-Dominguez Y, Algara M, Severiche-Mena C, Smolderen KG, Mena-Hurtado C. Risk profiles, access to care, and outcomes in Hispanics hospitalized for lower extremity peripheral artery disease. Journal Of Vascular Surgery 2022, 77: 216-224.e15. PMID: 36037965, DOI: 10.1016/j.jvs.2022.08.021.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseLower extremity peripheral artery diseaseNon-Hispanic whitesEmergency departmentPAD careArtery diseaseRisk factorsSevere peripheral artery diseaseChronic limb-threatening ischemiaRisk profileNational Inpatient Sample dataCardiovascular risk factorsLimb-threatening ischemiaPatients' sociodemographic characteristicsWorse clinical outcomesMultivariable logistic regressionAssociation of ethnicityLength of stayHealth care consumptionHealth care coveragePAD hospitalizationsPrior amputationEndovascular revascularizationED admissionRenal failure
2021
Relation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients With Coronavirus Disease 2019 (from the Yale COVID-19 Cardiovascular Registry)
Pareek M, Singh A, Vadlamani L, Eder M, Pacor J, Park J, Ghazizadeh Z, Heard A, Cruz-Solbes AS, Nikooie R, Gier C, Ahmed ZV, Freeman JV, Meadows J, Smolderen KGE, Lampert R, Velazquez EJ, Ahmad T, Desai NR. Relation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients With Coronavirus Disease 2019 (from the Yale COVID-19 Cardiovascular Registry). The American Journal Of Cardiology 2021, 146: 99-106. PMID: 33539857, PMCID: PMC7849530, DOI: 10.1016/j.amjcard.2021.01.029.Peer-Reviewed Original ResearchConceptsCardiovascular risk factorsCoronavirus disease 2019Risk factorsHigher troponin TCardiovascular diseaseCardiovascular eventsHospitalized patientsLaboratory findingsMental statusDisease 2019Multivariable binary logistic regression analysisTroponin TMajor adverse cardiovascular eventsPre-existing cardiovascular diseaseHigher C-reactive proteinCOVID-19 positive patientsPredictors of MACEPrevious ventricular arrhythmiaUse of P2YAdverse cardiovascular eventsProspective cohort studyTertiary care centerC-reactive proteinBinary logistic regression analysisPoor prognostic marker
2018
PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease
Smolderen KG, Gosch K, Patel M, Jones WS, Hirsch AT, Beltrame J, Fitridge R, Shishehbor MH, Denollet J, Vriens P, Heyligers J, Stone MEd N, Aronow H, Abbott JD, Labrosciano C, Tutein-Nolthenius R, A Spertus J. PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease. Circulation Cardiovascular Quality And Outcomes 2018, 11: e003860. PMID: 29440123, DOI: 10.1161/circoutcomes.117.003860.Peer-Reviewed Original ResearchMeSH KeywordsAgedAustraliaCardiovascular AgentsExercise TherapyFemaleHealth StatusHealth Status IndicatorsHealthcare DisparitiesHumansIntermittent ClaudicationLife StyleMaleMiddle AgedMulticenter Studies as TopicNetherlandsPatient Outcome AssessmentPeripheral Arterial DiseaseProspective StudiesQuality of LifeRegistriesResearch DesignRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsHealth status outcomesHealth statusMedical historyMedical recordsStatus outcomesAbnormal ankle-brachial indexPAD-related hospitalizationAnkle-brachial indexCardiovascular risk factorsMajor cardiovascular eventsPatients' medical recordsComparative effectiveness studiesHealth status dataPatient's medical historyPatients' health statusQuality of lifeClaudication symptomsEligible patientsCardiovascular eventsPAD symptomsPatient characteristicsClinician adherenceRisk stratificationLifestyle factorsFunctional status
2015
Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study
Smolderen KG, Strait KM, Dreyer RP, D'Onofrio G, Zhou S, Lichtman JH, Geda M, Bueno H, Beltrame J, Safdar B, Krumholz HM, Spertus JA. Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study. Journal Of The American Heart Association 2015, 4: e001424. PMID: 25836055, PMCID: PMC4579927, DOI: 10.1161/jaha.114.001424.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDepressive symptomsLifetime historyMyocardial infarctionRisk factorsYoung acute myocardial infarctionYoung AMI Patients (VIRGO) studyMore cardiovascular risk factorsYoung womenCardiovascular risk factorsTime of admissionAdverse medical outcomesMore depressive symptomsLow socioeconomic profileAMI severityVIRGO StudyCardiovascular riskChart abstractionYounger patientsClinical profileRelevant sex differencesPatient profilesAMI admissionsMedical outcomesPatients
2012
Self-reported symptoms on questionnaires and anatomic lesions on duplex ultrasound examinations in patients with peripheral arterial disease
van Zitteren M, Vriens PW, Heyligers JM, Burger DH, Nooren MJ, de Fijter WM, Denollet J, Smolderen KG. Self-reported symptoms on questionnaires and anatomic lesions on duplex ultrasound examinations in patients with peripheral arterial disease. Journal Of Vascular Surgery 2012, 55: 1025-1034.e2. PMID: 22244858, DOI: 10.1016/j.jvs.2011.10.115.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsCross-Sectional StudiesFemaleFollow-Up StudiesHumansIntermittent ClaudicationLogistic ModelsLower ExtremityMaleMultivariate AnalysisOdds RatioPain MeasurementPeripheral Arterial DiseaseRisk FactorsSelf ReportSeverity of Illness IndexSurveys and QuestionnairesUltrasonography, Doppler, DuplexConceptsPeripheral arterial diseaseCardiovascular risk factorsDuplex ultrasound examinationDistal lesionsProximal lesionsLesion locationLeg symptomsPatient characteristicsSelf-reported symptomsArterial diseaseRisk factorsUltrasound examinationLower extremity peripheral arterial diseaseVascular surgery outpatient clinicMultivariable logistic regression analysisExertional leg symptomsNew-onset symptomsCardiovascular risk profileSurgery outpatient clinicMain outcome measuresCross-sectional studyFurther diagnostic imagingLogistic regression analysisTailor-made managementPAD subgroups
2010
One-year costs associated with cardiovascular disease in Canada: Insights from the REduction of Atherothrombosis for Continued Health (REACH) registry
Smolderen KG, Bell A, Lei Y, Cohen EA, Steg PG, Bhatt DL, Mahoney EM, investigators O. One-year costs associated with cardiovascular disease in Canada: Insights from the REduction of Atherothrombosis for Continued Health (REACH) registry. Canadian Journal Of Cardiology 2010, 26: e297-e305. PMID: 20931098, PMCID: PMC2954538, DOI: 10.1016/s0828-282x(10)70437-2.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseContinued Health (REACH) RegistryReduction of AtherothrombosisCardiovascular risk factorsCoronary artery diseaseArterial bedMedication useHospitalization costsAtherothrombotic diseaseArtery diseaseMedication costsCerebrovascular diseaseHealth registriesRisk factorsEconomic burdenMore cardiovascular risk factorsAnnual hospitalization costsCardiovascular-related hospitalizationsMean hospitalization costOne-year followOne-year costsCardiovascular eventsPolyvascular diseaseAnnual hospitalizationsClinical factors
2008
Depressive symptoms in peripheral arterial disease: A follow-up study on prevalence, stability, and risk factors
Smolderen KG, Aquarius AE, de Vries J, Smith OR, Hamming JF, Denollet J. Depressive symptoms in peripheral arterial disease: A follow-up study on prevalence, stability, and risk factors. Journal Of Affective Disorders 2008, 110: 27-35. PMID: 18237784, DOI: 10.1016/j.jad.2007.12.238.Peer-Reviewed Original ResearchConceptsAnkle-brachial indexPeripheral arterial diseaseDepressive symptomsPAD patientsArterial diseaseRisk factorsDepressed patientsSymptomatic lower extremity peripheral arterial diseaseLower extremity peripheral arterial diseaseEpidemiological Studies Depression ScaleTreadmill walking distanceCardiovascular risk factorsCoronary artery diseasePsychotropic medication useRelevant depressive symptomsOnly baseline dataPAD severityArtery diseaseMedication usePatient groupPoor prognosisClinical correlatesDepression ScaleClinical careWalking distance