2016
Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice
Seifert L, Werba G, Tiwari S, Ly N, Nguy S, Alothman S, Alqunaibit D, Avanzi A, Daley D, Barilla R, Tippens D, Torres-Hernandez A, Hundeyin M, Mani VR, Hajdu C, Pellicciotta I, Oh P, Du K, Miller G. Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice. Gastroenterology 2016, 150: 1659-1672.e5. PMID: 26946344, PMCID: PMC4909514, DOI: 10.1053/j.gastro.2016.02.070.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaImmune suppressive phenotypeT cell responsesRadiation therapyT cellsTumor growthControl micePancreatic tumorsT cell-mediated anti-tumor responsesAdvanced unresectable pancreatic ductal adenocarcinomaAnti-tumor T cell responsesInvasive pancreatic ductal adenocarcinomaSuppress T cell responsesUnresectable pancreatic ductal adenocarcinomaMurine pancreatic ductal adenocarcinomaPancreatic intraepithelial lesionsAnti-tumor responseT helper 2Treatment of patientsRegulatory cell phenotypeM2-like phenotypePhenotype of macrophagesAdoptive transferKC miceUnexposed mice
2013
Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair
Guttmann DM, Hart L, Du K, Seletsky A, Koumenis C. Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair. International Journal Of Radiation Oncology • Biology • Physics 2013, 87: 168-175. PMID: 23849696, DOI: 10.1016/j.ijrobp.2013.05.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell Line, TumorDNA RepairDNA, NeoplasmDNA-Binding ProteinsGene Knockdown TechniquesHead and Neck NeoplasmsHistonesHSP27 Heat-Shock ProteinsHumansMiceMice, NudeOligonucleotidesProtein Serine-Threonine KinasesRadiation ToleranceRNA, Small InterferingTumor Suppressor ProteinsConceptsShort hairpin RNANeck cancer cell linesCancer cell linesNeck cancerNude miceTumor growthHsp27 knockdownRadiotherapy of headFractionated radiation therapyFaDu human headEffect of Hsp27Cell linesEffective clinical agentRole of HSP27LNA treatmentFlank tumorsRadiation therapyTumor xenograftsDeoxyribonucleic acid repairTumor radiosensitizationClonogenic survivalClinical agentsHairpin RNAHSP27DNA repair signaling