Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice
Seifert L, Werba G, Tiwari S, Ly N, Nguy S, Alothman S, Alqunaibit D, Avanzi A, Daley D, Barilla R, Tippens D, Torres-Hernandez A, Hundeyin M, Mani VR, Hajdu C, Pellicciotta I, Oh P, Du K, Miller G. Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice. Gastroenterology 2016, 150: 1659-1672.e5. PMID: 26946344, PMCID: PMC4909514, DOI: 10.1053/j.gastro.2016.02.070.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaImmune suppressive phenotypeT cell responsesRadiation therapyT cellsTumor growthControl micePancreatic tumorsT cell-mediated anti-tumor responsesAdvanced unresectable pancreatic ductal adenocarcinomaAnti-tumor T cell responsesInvasive pancreatic ductal adenocarcinomaSuppress T cell responsesUnresectable pancreatic ductal adenocarcinomaMurine pancreatic ductal adenocarcinomaPancreatic intraepithelial lesionsAnti-tumor responseT helper 2Treatment of patientsRegulatory cell phenotypeM2-like phenotypePhenotype of macrophagesAdoptive transferKC miceUnexposed mice