2018
Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis
Chadi SA, Malcomson L, Ensor J, Riley RD, Vaccaro CA, Rossi GL, Daniels IR, Smart NJ, Osborne ME, Beets GL, Maas M, Bitterman DS, Du K, Gollins S, Myint A, Smith FM, Saunders MP, Scott N, O'Dwyer ST, de Castro Araujo RO, Valadao M, Lopes A, Hsiao CW, Lai CL, Smith RK, Paulson EC, Appelt A, Jakobsen A, Wexner SD, Habr-Gama A, Julião G, Perez R, Renehan AG. Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology 2018, 3: 825-836. PMID: 30318451, DOI: 10.1016/s2468-1253(18)30301-7.Peer-Reviewed Original ResearchConceptsClinical complete responseIndividual participant dataComplete responseLocal regrowthRectal cancerCumulative incidenceParticipant dataNeoadjuvant chemoradiotherapyHazard ratioSustained clinical complete responseProportion of patientsCenter heterogeneityRecent systematic reviewCox frailty modelStage cT1CT2 tumorsMajor surgeryPrimary outcomeTreatment characteristicsChemoradiotherapyLower riskPatientsStudy heterogeneitySystematic reviewNovel management strategies
2017
Biomarkers that Predict Response to Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer
Oh P, Du K. Biomarkers that Predict Response to Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer. Current Colorectal Cancer Reports 2017, 13: 276-283. DOI: 10.1007/s11888-017-0376-3.Peer-Reviewed Original ResearchAdvanced rectal cancerRectal cancerNeoadjuvant chemoradiationComplete responsePathologic complete responseStandard of careBowel functionNeoadjuvant therapyOverall survivalTumor responsePotential complicationsChemoradiationBiologic factorsTreatment correlatesCancerSurgeryRecent reportsCurrent literatureBiomarkersResponseComplicationsPatientsTherapyCare
2016
Methylation profiling of locally advanced rectal cancer (LARC): Exploration of potential predictive markers for neoadjuvant chemoradiation (NACR).
Guo S, Melamed J, Eze O, Bowman C, Ahmed S, Moore H, Loomis C, Heguy A, Brody R, Morrison D, Serrano J, Du K, Wu J, Ryan T, Cohen D, Gu P, Goldberg J, Snuderl M, Leichman L, Leichman C. Methylation profiling of locally advanced rectal cancer (LARC): Exploration of potential predictive markers for neoadjuvant chemoradiation (NACR). Journal Of Clinical Oncology 2016, 34: 614-614. DOI: 10.1200/jco.2016.34.4_suppl.614.Peer-Reviewed Original ResearchTotal mesorectal excisionNeoadjuvant chemoradiationLaser capture microdissectionRectal cancerInvasive carcinomaNormal epitheliumNew York University HospitalFuture prospective trialsComplete pathologic responseAdvanced rectal cancerPotential predictive markerOptimal clinical outcomesPathologic responseProspective trialMesorectal excisionClinical outcomesColorectal cancerInflammatory cellsPathologic outcomesPredictive biomarkersPredictive markerUniversity HospitalPathologic resultsH3K27me3 immunohistochemistryClinical cohort
2015
Predictors of Complete Response and Disease Recurrence Following Chemoradiation for Rectal Cancer
Bitterman DS, Salgado L, Moore HG, Sanfilippo NJ, Gu P, Hatzaras I, Du KL. Predictors of Complete Response and Disease Recurrence Following Chemoradiation for Rectal Cancer. Frontiers In Oncology 2015, 5: 286. PMID: 26734570, PMCID: PMC4686647, DOI: 10.3389/fonc.2015.00286.Peer-Reviewed Original ResearchDistant metastasis-free survivalDisease-free survivalComplete responseLocoregional controlCarcinoembryonic antigenAnal vergeIndependent predictorsRectal cancerTumor sizeCR groupNode-positive rectal cancerThree-year locoregional controlNode-positive diseaseDistance of tumorNon-operative managementMetastasis-free survivalLong-term outcomesTreatment response evaluationDefinitive chemoradiationRectal patientsNeoadjuvant chemoradiationMost patientsNode positivityOverall survivalSelect patientsPredictors of Complete Response and Recurrence Following Neoadjuvant Chemoradiation Therapy in Rectal Cancer
Bitterman D, Resende-Salgado L, Moore H, Sanfilippo N, Gu P, Hatzaras I, Du K. Predictors of Complete Response and Recurrence Following Neoadjuvant Chemoradiation Therapy in Rectal Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e145-e146. DOI: 10.1016/j.ijrobp.2015.07.919.Peer-Reviewed Original ResearchDosimetric Comparison of Proton Therapy, Volumetric Modulated Arc Therapy, and 3-D Conformal Radiation Therapy for the Treatment of Rectal Cancer: An Early Community Experience
Cooper B, Qu J, Chon B, Tsai H, Mah D, Du K, DeWyngaert J, Yeh B. Dosimetric Comparison of Proton Therapy, Volumetric Modulated Arc Therapy, and 3-D Conformal Radiation Therapy for the Treatment of Rectal Cancer: An Early Community Experience. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e176. DOI: 10.1016/j.ijrobp.2015.07.999.Peer-Reviewed Original ResearchRadiation therapy improves survival in rectal small cell cancer - Analysis of Surveillance Epidemiology and End Results (SEER) data
Modrek AS, Hsu HC, Leichman CG, Du KL. Radiation therapy improves survival in rectal small cell cancer - Analysis of Surveillance Epidemiology and End Results (SEER) data. Radiation Oncology 2015, 10: 101. PMID: 25902707, PMCID: PMC4464878, DOI: 10.1186/s13014-015-0411-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Agents, AlkylatingAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Small CellCombined Modality TherapyDigestive System Surgical ProceduresFemaleHumansKaplan-Meier EstimateMaleMiddle AgedOrganoplatinum CompoundsProportional Hazards ModelsRectal NeoplasmsRetrospective StudiesSEER ProgramSurvival AnalysisUnited StatesConceptsRadiation therapyOverall survivalRectal cancerSurveillance EpidemiologyCell carcinomaSEER dataMultivariate Cox proportional hazards modelCox proportional hazards modelBackgroundSmall cell carcinomaMethodsThe SEER databaseCancer-directed therapyEnd Results (SEER) databaseUnadjusted hazard ratioEnd Results (SEER) dataKaplan-Meier methodOverall survival rateYear of diagnosisSmall cell carcinomaSignificant survival advantagePearson's chi-square testProportional hazards modelOnly significant factorChi-square testChemotherapy usageLocoregional cases
2014
Outcomes of rectal cancer with liver oligometastases
Resende Salgado L, Hsu H, Du K. Outcomes of rectal cancer with liver oligometastases. Journal Of Gastrointestinal Oncology 2014, 5: 414-20. PMID: 25436119, PMCID: PMC4226821, DOI: 10.3978/j.issn.2078-6891.2014.078.Peer-Reviewed Original ResearchRectal cancer patientsTotal mesorectal excisionProgression-free survivalCourse chemoradiationLiver metastasesOverall survivalCancer patientsLocal controlRectal cancerDistant metastasisMean PFS timeOligometastatic colorectal cancerOligometastatic rectal cancerPelvic lymph nodesKaplan-Meier methodMulti-modality treatment approachSingle institution experienceTime of diagnosisGoals of careKaplan-Meier analysisEquivalent local controlMean survival timeLong-term survivalYears of ageCensoring deaths
2013
Radiation Therapy Improves Survival in Small Cell Rectal Cancer: Analysis of Surveillance, Epidemiology, and End Results (SEER) Data
Hsu H, Leichman C, Du K. Radiation Therapy Improves Survival in Small Cell Rectal Cancer: Analysis of Surveillance, Epidemiology, and End Results (SEER) Data. International Journal Of Radiation Oncology • Biology • Physics 2013, 87: s188. DOI: 10.1016/j.ijrobp.2013.06.484.Peer-Reviewed Original Research