2012
Genome-wide association study of Tourette's syndrome
Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff R, Wagner M, Moessner R, Mirel D, Posthuma D, Sabatti C, Eskin E, Conti D, Knowles J, Ruiz-Linares A, Rouleau G, Purcell S, Heutink P, Oostra B, McMahon W, Freimer N, Cox N, Pauls D. Genome-wide association study of Tourette's syndrome. Molecular Psychiatry 2012, 18: 721-728. PMID: 22889924, PMCID: PMC3605224, DOI: 10.1038/mp.2012.69.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityCase-Control StudiesChromosomes, Human, Pair 9FemaleFibrillar CollagensGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansInternational CooperationMaleMeta-Analysis as TopicObsessive-Compulsive DisorderPolymorphism, Single NucleotideTourette SyndromeWhite PeopleYoung AdultConceptsGenome-wide association studiesFirst genome-wide association studyAssociation studiesTop signalsFull genetic architectureAncestry-matched controlsEuropean ancestry samplesGenetic architectureGWAS dataComplex inheritanceEuropean-derived populationsSusceptibility variantsSusceptibility genesEventual identificationEuropean ancestryCosta RicaChromosome 9q32Familial recurrence rateNorth AmericaComplete understandingAmerican populationCentral ValleyNeuropsychiatric diseasesDevelopmental disordersGenes
2010
Additional support for the association of SLITRK1 var321 and Tourette syndrome
O'Roak B, Morgan T, Fishman D, Saus E, Alonso P, Gratacòs M, Estivill X, Teltsh O, Kohn Y, Kidd K, Cho J, Lifton R, State M. Additional support for the association of SLITRK1 var321 and Tourette syndrome. Molecular Psychiatry 2010, 15: 447-450. PMID: 20351724, PMCID: PMC3292207, DOI: 10.1038/mp.2009.105.Peer-Reviewed Original Research
2004
Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region
Paschou P, Feng Y, Pakstis A, Speed W, DeMille M, Kidd J, Jaghori B, Kurlan R, Pauls D, Sandor P, Barr C, Kidd K. Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region. American Journal Of Human Genetics 2004, 75: 545-560. PMID: 15303240, PMCID: PMC1182043, DOI: 10.1086/424389.Peer-Reviewed Original ResearchMeSH KeywordsC-Reactive ProteinChromosome MappingChromosomes, Human, Pair 17Gene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumLod ScoreMicrosatellite RepeatsMicrotubule-Associated ProteinsNerve Tissue ProteinsPedigreePolymorphism, Single NucleotideTourette SyndromeWhite PeopleConceptsSingle nucleotide polymorphismsLinkage disequilibriumSusceptibility regionsThree-site haplotypesPutative susceptibility regionsBackground linkage disequilibriumSignificant association resultsIndication of linkageNonparametric LOD scoreGenomic regionsThree-marker haplotypeComplex genetic backgroundAdditional microsatellite markersFine mappingGenetic basisHigher LD valuesMicrosatellite markersExpression profilesAssociation resultsTransmission/disequilibrium testChromosome 17Genetic componentGenetic backgroundGenesLOD score
1999
Genome scan for linkage to Gilles de la Tourette syndrome
Barr C, Wigg K, Pakstis A, Kurlan R, Pauls D, Kidd K, Tsui L, Sandor P. Genome scan for linkage to Gilles de la Tourette syndrome. American Journal Of Medical Genetics 1999, 88: 437-445. PMID: 10402514, DOI: 10.1002/(sici)1096-8628(19990820)88:4<437::aid-ajmg24>3.0.co;2-e.Peer-Reviewed Original Research
1995
The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome
Gelernter J, Vandenbergh D, Kruger S, Pauls D, Kurlan R, Pakstis A, Kidd K, Uhl G. The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome. Genomics 1995, 30: 459-463. PMID: 8825631, DOI: 10.1006/geno.1995.1265.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterAttention deficit disorderDopaminergic neuronsPresynaptic reuptakeSpecific localizationPsychiatric illnessPsychostimulant drugsChromosome 5pCocaine-induced paranoiaSyndromeDeficit disorderSLC6A3ScoresMajor siteLinkage studiesNegative lod scoresMarkersTransporter protein geneAssignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome
Gelernter J, Rao P, Pauls D, Hamblin M, Sibley D, Kidd K. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome. Genomics 1995, 26: 207-209. PMID: 7601444, DOI: 10.1016/0888-7543(95)80202-w.Peer-Reviewed Original ResearchConceptsGenetic linkageSomatic cell hybridsInteresting candidate genesPairwise linkage analysisCell hybridsNovel serotonin receptorCandidate genesChromosome 10Linkage analysisSouthern blotGenesExtended pedigreesLOD scoreReceptor geneLociGenetic polymorphismsHTR7PolymorphismReceptorsLIPED computer programDNALinkageHybridizationNeuropsychiatric disordersPedigree
1991
Linkage and Tourette syndrome
Heutink P, Sandkuyl L, Van De Wetering B, Oostra B, Weber J, Wilkie P, Devor E, Pakstis A, Pauls D, Kidd K. Linkage and Tourette syndrome. The Lancet 1991, 337: 122-123. PMID: 1670715, DOI: 10.1016/0140-6736(91)90788-q.Peer-Reviewed Original Research
1990
Haplotype of multiple polymorphisms resolved by enzymatic amplification of single DNA molecules.
Ruano G, Kidd K, Stephens J. Haplotype of multiple polymorphisms resolved by enzymatic amplification of single DNA molecules. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 6296-6300. PMID: 1974719, PMCID: PMC54520, DOI: 10.1073/pnas.87.16.6296.Peer-Reviewed Original ResearchBase SequenceDeoxyribonucleases, Type II Site-SpecificDNAGenetic Carrier ScreeningGenetic LinkageHaplotypesHumansMolecular Sequence DataNucleic Acid Amplification TechniquesOligonucleotide ProbesPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthTourette SyndromeWhite PeopleSegregation and Linkage Analyses of Tourette's Syndrome and Related Disorders
PAULS D, PAKSTIS A, KURLAN R, KIDD K, LECKMAN J, COHEN D, KIDD J, COMO P, SPARKES R. Segregation and Linkage Analyses of Tourette's Syndrome and Related Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 195-203. PMID: 2324061, DOI: 10.1097/00004583-199003000-00007.Peer-Reviewed Original Research
1989
Linkage Analysis Approach to Hereditary Movement Disorders
Kurlan R, Kidd K, Pauls D. Linkage Analysis Approach to Hereditary Movement Disorders. Journal Of Neurogenetics 1989, 5: 161-171. PMID: 2569508, DOI: 10.3109/01677068909066206.Peer-Reviewed Original Research
1987
Severity of Tourette's Syndrome in One Large Kindred: Implication for Determination of Disease Prevalence Rate
Kurlan R, Behr J, Medved L, Shoulson I, Pauls D, Kidd K. Severity of Tourette's Syndrome in One Large Kindred: Implication for Determination of Disease Prevalence Rate. JAMA Neurology 1987, 44: 268-269. PMID: 3469941, DOI: 10.1001/archneur.1987.00520150024013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCanadaChildChild, PreschoolFamilyFemaleHumansMaleMiddle AgedSurveys and QuestionnairesTourette SyndromeConceptsChronic motor ticsPrevalence ratesTourette syndromeSeverity of illnessAccurate prevalence ratesDisease prevalence ratesAutosomal dominant transmissionMotor ticsTic disordersVocal ticsMedical attentionStandardized questionnaireMedical careSyndromeLarge MennoniteApparent autosomal dominant transmissionDominant transmissionFamily membersSeverityMost casesIllnessCareSearching for Major Genes for Psychiatric Disorders
Kidd K. Searching for Major Genes for Psychiatric Disorders. Novartis Foundation Symposia 1987, 130: 184-196. PMID: 2894929, DOI: 10.1002/9780470513507.ch11.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderChromosome MappingGenesGenetic LinkageHumansPolymorphism, Restriction Fragment LengthSchizophreniaTourette SyndromeConceptsPsychiatric disordersManic-depressive illnessMajor psychiatric disordersGenetic linkage studiesDepressive illnessAetiological factorsLinkage studiesNeurochemical complexityCommon disorderBiochemical abnormalitiesFamilial clusteringMajor genetic componentGenetic factorsDisordersRestriction fragment length polymorphismReasonable evidenceFragment length polymorphismLength polymorphismGenetic componentEvidenceCandidate genesIllnessAbnormalitiesSuspicionBrain
1986
Gilles de la Tourette's Syndrome and Attention Deficit Disorder With Hyperactivity: Evidence Against a Genetic Relationship
Pauls D, Hurst C, Kruger S, Leckman J, Kidd K, Cohen D. Gilles de la Tourette's Syndrome and Attention Deficit Disorder With Hyperactivity: Evidence Against a Genetic Relationship. JAMA Psychiatry 1986, 43: 1177-1179. PMID: 3465279, DOI: 10.1001/archpsyc.1986.01800120063012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityConnecticutFemaleHumansMaleRiskTourette SyndromeFamilial Tourette's syndrome: report of a large pedigree and potential for linkage analysis.
Kurlan R, Behr J, Medved L, Shoulson I, Pauls D, Kidd J, Kidd K. Familial Tourette's syndrome: report of a large pedigree and potential for linkage analysis. Neurology 1986, 36: 772-6. PMID: 3458031, DOI: 10.1212/wnl.36.6.772.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildChild, PreschoolFemaleGenetic LinkageHumansMaleMiddle AgedPedigreeTourette SyndromeConceptsChronic motor ticsTourette syndromeDefinite Tourette's syndromePermanent lymphoblastoid cell linesDSM-III criteriaAutosomal dominant patternFamily membersClinical featuresMotor ticsVocal ticsLymphoblastoid cell linesStandardized questionnaireLarge MennoniteCell linesSyndromeDominant patternIndependent ratings
1985
A Twin Study of Tourette Syndrome
Price R, Kidd K, Cohen D, Pauls D, Leckman J. A Twin Study of Tourette Syndrome. JAMA Psychiatry 1985, 42: 815-820. PMID: 3860194, DOI: 10.1001/archpsyc.1985.01790310077011.Peer-Reviewed Original Research
1984
The Risk of Tourette's Syndrome and Chronic Multiple Tics among Relatives of Tourette's Syndrome Patients Obtained by Direct Interview
PAULS D, KRUGER S, LECKMAN J, COHEN D, KIDD K. The Risk of Tourette's Syndrome and Chronic Multiple Tics among Relatives of Tourette's Syndrome Patients Obtained by Direct Interview. Journal Of The American Academy Of Child & Adolescent Psychiatry 1984, 23: 134-137. PMID: 6585415, DOI: 10.1097/00004583-198403000-00003.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansInterviews as TopicMalePsychiatric Status Rating ScalesRiskTic DisordersTourette Syndrome
1982
The Epidemiology of Tourette's Syndrome: A Pilot Study
Jagger J, Prusoff B, Cohen D, Kidd K, Carbonari C, John K. The Epidemiology of Tourette's Syndrome: A Pilot Study. Schizophrenia Bulletin 1982, 8: 267-278. PMID: 6955942, DOI: 10.1093/schbul/8.2.267.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttitudeChildChild DevelopmentChild, PreschoolFemaleHaloperidolHumansMaleMiddle AgedPilot ProjectsTourette SyndromeConceptsSyndrome patientsDiagnosis of TSTourette syndrome patientsTourette Syndrome AssociationUnpleasant side effectsMost patientsSelf-report questionnairesSyndrome AssociationEffective treatmentPatient membersSide effectsAlternative treatmentTourette syndromeDiscontinued usePatientsPilot studyHaloperidolSyndromeTreatmentQuestionnaireAttentional difficultiesSymptomsEpidemiologyDiagnosisGenetic Strategies for the Analysis of Childhood Behavioral Traits
Pauls D, Kidd K. Genetic Strategies for the Analysis of Childhood Behavioral Traits. Schizophrenia Bulletin 1982, 8: 253-266. PMID: 6955941, DOI: 10.1093/schbul/8.2.253.Peer-Reviewed Original ResearchGenetic hypotheses for Tourette syndrome.
Kidd K, Pauls D. Genetic hypotheses for Tourette syndrome. Advances In Neurology 1982, 35: 243-9. PMID: 6959493.Peer-Reviewed Original Research
1981
Familial Pattern and Transmission of Gilles de la Tourette Syndrome and Multiple Tics
Pauls D, Cohen D, Heimbuch R, Detlor J, Kidd K. Familial Pattern and Transmission of Gilles de la Tourette Syndrome and Multiple Tics. JAMA Psychiatry 1981, 38: 1091-1093. PMID: 6945827, DOI: 10.1001/archpsyc.1981.01780350025002.Peer-Reviewed Original Research