1995
The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome
Gelernter J, Vandenbergh D, Kruger S, Pauls D, Kurlan R, Pakstis A, Kidd K, Uhl G. The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome. Genomics 1995, 30: 459-463. PMID: 8825631, DOI: 10.1006/geno.1995.1265.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterAttention deficit disorderDopaminergic neuronsPresynaptic reuptakeSpecific localizationPsychiatric illnessPsychostimulant drugsChromosome 5pCocaine-induced paranoiaSyndromeDeficit disorderSLC6A3ScoresMajor siteLinkage studiesNegative lod scoresMarkersTransporter protein gene
1993
Physical and Genetic Maps for Chromosome 10
Lichter J, Difilippantonio M, Pakstis A, Goodfellow P, Ward D, Kidd K. Physical and Genetic Maps for Chromosome 10. Genomics 1993, 16: 320-324. PMID: 8314570, DOI: 10.1006/geno.1993.1192.Peer-Reviewed Original ResearchConceptsChromosome 10Physical mapOrder of lociGenetic mapLinkage mapGenetic distanceFemale mapGenetic linkage studiesMetaphase chromosomesPolymorphic lociNew lociQ armLociFractional lengthCentromeresLinkage studiesFishPhysical distanceRecombinationCentimorgansChromosomesDistance estimatesFemalesMalesFluorescence
1992
Localization of the gene for MEN 2A.
Lichter J, Difilippantonio M, Wu J, Miller D, Ward D, Goodfellow P, Kidd K. Localization of the gene for MEN 2A. Henry Ford Hospital Medical Journal 1992, 40: 199-204. PMID: 1362405.Peer-Reviewed Original ResearchConceptsGene mapping techniquesYeast artificial chromosomesMapping panelPericentromeric regionArtificial chromosomesGenetic linkage studiesChromosome 10GenesSitu hybridizationLinkage studiesChromosomesMBMultiple endocrine neoplasia type 2A syndromeDNAHybridizationRegionConsistent orderSmall regionLocalizationFluorescenceMarkers
1990
Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region
Wu J, Kidd K. Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region. Human Genetics 1990, 84: 279-282. PMID: 1968036, DOI: 10.1007/bf00200575.Peer-Reviewed Original ResearchConceptsAlpha satellite DNAExtensive sequence polymorphismSatellite DNAPericentromeric regionSequence polymorphismsExcellent genetic markerCentromeric regionsDNA markersGenetic markersEnzyme PstILOD scoreClose linkagePositive lod scoresLinkage studiesDNAType 2AIndependent supportPolymorphismCentromeresMorphsMarkersRBP3LociDistance relationshipsEcoRVThe locus for the medium-chain acyl-CoA dehydrogenase gene on chromosome 1 is highly polymorphic
Kidd J, Matsubara Y, Castiglione C, Tanaka K, Kidd K. The locus for the medium-chain acyl-CoA dehydrogenase gene on chromosome 1 is highly polymorphic. Genomics 1990, 6: 89-93. PMID: 1968047, DOI: 10.1016/0888-7543(90)90451-y.Peer-Reviewed Original ResearchConceptsRestriction fragment length polymorphismMedium-chain acyl-CoA dehydrogenase (MCAD) geneAcyl-CoA dehydrogenase geneSomatic cell studiesMedium-chain acyl-CoA dehydrogenaseSignificant linkage disequilibriumAcyl-CoA dehydrogenaseLinkage mappingDehydrogenase geneRegional assignmentChromosome 1Fragment length polymorphismGenetic studiesLinkage analysisLinkage disequilibriumSitu hybridizationLength polymorphismLinkage studiesPGM1Clinical genetic studiesACADMGenesLociCell localizationRFLP systems
1989
The β subunit locus of the human fibronectin receptor: DNA restriction fragment length polymorphism and linkage mapping studies
Wu J, Giuffra L, Goodfellow P, Myers S, Carson N, Anderson L, Hoyle L, Simpson N, Kidd K. The β subunit locus of the human fibronectin receptor: DNA restriction fragment length polymorphism and linkage mapping studies. Human Genetics 1989, 83: 383-390. PMID: 2572537, DOI: 10.1007/bf00291386.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 1Chromosomes, Human, Pair 10Chromosomes, Human, Pair 17Chromosomes, Human, Pair 21DNADNA ProbesDNA, NeoplasmFemaleGenetic LinkageGenetic MarkersHaplotypesHumansMaleMultiple Endocrine NeoplasiaPolymorphism, Restriction Fragment LengthReceptors, FibronectinReceptors, ImmunologicConceptsRestriction fragment length polymorphismHuman fibronectin receptorCDNA clonesFragment length polymorphismLinkage analysisDNA restriction fragment length polymorphismsMultiple restriction fragment length polymorphismsPolymorphism information content (PIC) valuesFibronectin receptorHighest polymorphism information content valuePartial cDNA cloneInformation content valuesLength polymorphismLinkage studiesPairwise linkage analysisSouthern blot analysisTypes of polymorphismsChromosome 10 markersGenomic clonesPericentromeric regionTransmembrane proteinDNA markersGenetic linkage studiesDNA sequencesSingle locus
1988
Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree
Kennedy J, Giuffra L, Moises H, Cavalli-Sforza L, Pakstis A, Kidd J, Castiglione C, Sjogren B, Wetterberg L, Kidd K. Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 1988, 336: 167-170. PMID: 2903450, DOI: 10.1038/336167a0.Peer-Reviewed Original ResearchConceptsImportant pathogenic roleGenetic factorsSevere mental illnessAetiologic factorsChronic coursePathogenic roleProximal long armGlucocorticoid receptorMental illnessSchizophreniaSchizophrenia casesLinkage of schizophreniaGenetic linkage studiesFamily studiesLong armDistal long armMarkersChromosome 5Linkage studiesSwedish pedigreeArmLinkage ProjectIllnessStrong evidenceFactorsThe human “interferon-β2/hepatocyte stimulating factor/interleukin-6” gene: DNA polymorphism studies and localization to chromosome 7p21
Bowcock A, Kidd J, Lathrop G, Daneshvar L, May L, Ray A, Sehgal P, Kidd K, Cavalli-Sforza L. The human “interferon-β2/hepatocyte stimulating factor/interleukin-6” gene: DNA polymorphism studies and localization to chromosome 7p21. Genomics 1988, 3: 8-16. PMID: 2906047, DOI: 10.1016/0888-7543(88)90152-8.Peer-Reviewed Original ResearchConceptsHybridoma growth factorChromosome 7 markersPolymorphic MspI siteDNA polymorphism studiesBase pair substitutionsDNA replicationDNA insertionFifth exonGene productsProtein responseEnzyme MspIAT dinucleotidesVariety of haplotypesBglI polymorphismFactor/interleukinGenesLinkage disequilibriumMspI sitePolymorphic sitesPair substitutionsMspILinkage studiesFactor 2Polymorphism studiesKb
1987
Research design considerations for linkage studies of affective disorders using recombinant DNA markers
Kidd K. Research design considerations for linkage studies of affective disorders using recombinant DNA markers. Journal Of Psychiatric Research 1987, 21: 551-557. PMID: 3326941, DOI: 10.1016/0022-3956(87)90104-x.Peer-Reviewed Original ResearchSearching for Major Genes for Psychiatric Disorders
Kidd K. Searching for Major Genes for Psychiatric Disorders. Novartis Foundation Symposia 1987, 130: 184-196. PMID: 2894929, DOI: 10.1002/9780470513507.ch11.Peer-Reviewed Original ResearchConceptsPsychiatric disordersManic-depressive illnessMajor psychiatric disordersGenetic linkage studiesDepressive illnessAetiological factorsLinkage studiesNeurochemical complexityCommon disorderBiochemical abnormalitiesFamilial clusteringMajor genetic componentGenetic factorsDisordersRestriction fragment length polymorphismReasonable evidenceFragment length polymorphismLength polymorphismGenetic componentEvidenceCandidate genesIllnessAbnormalitiesSuspicionBrain
1986
Family-Genetic Studies of Psychiatric Disorders: Developing Technologies
Weissman M, Merikangas K, John K, Wickramaratne P, Prusoff B, Kidd K. Family-Genetic Studies of Psychiatric Disorders: Developing Technologies. JAMA Psychiatry 1986, 43: 1104-1116. PMID: 3532996, DOI: 10.1001/archpsyc.1986.01800110090012.Peer-Reviewed Original ResearchConceptsPsychiatric disordersFamily genetic studiesMode of transmissionFuture genetic linkage studiesPsychiatric illnessChildhood manifestationsClinical practiceDiagnostic proceduresStudy designDisordersGenetic linkage studiesFamily studiesHomogeneous subgroupsLinkage studiesAdultsInformative familiesLinkage Analyses of Multiple Endocrine Neoplasia, Type 2A (MEN-2A) with 20 DNA Polymorphisms: 5% of the Genome Excluded
Kidd K, Kidd J, Castiglione C, Genel M, Darby J, Cavalli-Sforza L, Gusella J. Linkage Analyses of Multiple Endocrine Neoplasia, Type 2A (MEN-2A) with 20 DNA Polymorphisms: 5% of the Genome Excluded. Human Heredity 1986, 36: 243-249. PMID: 2875939, DOI: 10.1159/000153634.Peer-Reviewed Original Research
1985
Genetic analysis workshop III: Sampling considerations and assumptions in gene mapping
Price R, Kramer P, Pakstis A, Kidd K. Genetic analysis workshop III: Sampling considerations and assumptions in gene mapping. Genetic Epidemiology 1985, 2: 219-220. DOI: 10.1002/gepi.1370020220.Peer-Reviewed Original Research
1984
Amish study, IV: Genetic linkage study of pedigrees of bipolar probands
Kidd K, Egeland J, Molthan L, Pauls D, Kruger S, Messner K. Amish study, IV: Genetic linkage study of pedigrees of bipolar probands. American Journal Of Psychiatry 1984, 141: 1042-1048. PMID: 6331772, DOI: 10.1176/ajp.141.9.1042.Peer-Reviewed Original Research
1982
GENETIC LINKAGE MARKERS IN THE STUDY OF PSYCHIATRIC DISORDERS
Kidd K. GENETIC LINKAGE MARKERS IN THE STUDY OF PSYCHIATRIC DISORDERS. 1982, 459-466. DOI: 10.1016/b978-0-08-027987-9.50049-4.Peer-Reviewed Original Research