2012
The course of cognitive functioning over six months in individuals at clinical high risk for psychosis
Barbato M, Colijn MA, Keefe RS, Perkins DO, Woods SW, Hawkins KA, Christensen BK, Addington J. The course of cognitive functioning over six months in individuals at clinical high risk for psychosis. Psychiatry Research 2012, 206: 195-199. PMID: 23159196, PMCID: PMC3600156, DOI: 10.1016/j.psychres.2012.10.013.Peer-Reviewed Original ResearchConceptsClinical high riskCHR individualsComprehensive cognitive test batteryCognitive test batteryCognitive impairmentFuture longitudinal researchCognitive functioningCognitive performanceCognitive testsTest batteryLongitudinal researchCognitionPoor performanceLongitudinal changesPsychosisIndividualsParticipantsImpairmentBaseline participantsFunctioningPerformanceBatteriesResearchProdromeGlycine treatment of the risk syndrome for psychosis: Report of two pilot studies
Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies. European Neuropsychopharmacology 2012, 23: 931-940. PMID: 23089076, PMCID: PMC4028140, DOI: 10.1016/j.euroneuro.2012.09.008.Peer-Reviewed Original ResearchConceptsPilot studyRisk syndromeSyndrome patientsNegative symptomsShort-term pilot studyEffect sizeAdjunctive antipsychotic medicationOpen-label studyPatients meeting criteriaNMDA receptor functionDurability of effectPsychosis risk symptomsGlycine site agonistsGroup effect sizesWeeks of evaluationAntipsychotic medicationSyndrome subjectsPromising effect sizesTreatment needsLarge effect sizesMeeting criteriaCognitive impairmentReduced symptomsReceptor functionSymptoms
2004
Neuropsychological status of subjects at high risk for a first episode of psychosis
Hawkins KA, Addington J, Keefe RS, Christensen B, Perkins DO, Zipurksy R, Woods SW, Miller TJ, Marquez E, Breier A, McGlashan TH. Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophrenia Research 2004, 67: 115-122. PMID: 14984870, DOI: 10.1016/j.schres.2003.08.007.Peer-Reviewed Original ResearchConceptsFirst episodeFirst psychotic episodeLevel of impairmentSchizophrenia prodromePsychotic episodeHigh riskMulti-site studyProdromal interventionPopulation normsNeuropsychological examNeuropsychological StatusNeuropsychological functioningNormal intelligenceEpisodesSchizophrenia samplePsychosisSubjectsRiskStatusProdromeSchizophreniaImpairmentSeverity
2001
Estimated yield of early detection of prodromal or first episode patients by screening first degree relatives of schizophrenic patients
Woods S, Miller T, Davidson L, Hawkins K, Sernyak M, McGlashan T. Estimated yield of early detection of prodromal or first episode patients by screening first degree relatives of schizophrenic patients. Schizophrenia Research 2001, 52: 21-27. PMID: 11595388, DOI: 10.1016/s0920-9964(01)00158-x.Peer-Reviewed Original ResearchConceptsPopulation of relativesSchizophrenic patientsIntervention studiesNew casesEarly first episodeFirst-episode patientsChildren of patientsFirst-degree relativesEarly intervention studiesEpisode patientsLifetime riskProdromal patientsDegree relativesRisk groupsFirst episodeCurrent patientsPatientsRisk relativesSchizophrenic probandsEarly detectionSchizophrenia casesSchizophreniaAge distributionOnset distributionProbands
2000
Verbal Fluency Deficits Co‐Occur with Memory Deficits in Geriatric Patients at Risk for Dementia: Implications for the Concept of Mild Cognitive Impairment
Cottingham ME, Hawkins KA. Verbal Fluency Deficits Co‐Occur with Memory Deficits in Geriatric Patients at Risk for Dementia: Implications for the Concept of Mild Cognitive Impairment. Behavioural Neurology 2000, 22: 73-79. PMID: 20595739, PMCID: PMC5434323, DOI: 10.3233/ben-2009-0246.Peer-Reviewed Original ResearchConceptsMemory deficitsMemory groupFluency performanceMild cognitive impairmentLower memory performanceCognitive impairmentPhonemic fluency taskMemory test scoresAmnestic mild cognitive impairmentAlzheimer's disease (AD) displayMemory patientsMemory performanceFluency taskMemory scoresSemantic fluencyCognitive complaintsFluency testMemory abilityFluency scoresDisease displayTest scoresDeficitsClinical presentationGeriatric patientsPatient group