2018
Cognition among individuals along a spectrum of increased risk for Parkinson’s disease
Chahine LM, Urbe L, Caspell-Garcia C, Aarsland D, Alcalay R, Barone P, Burn D, Espay AJ, Hamilton JL, Hawkins KA, Lasch S, Leverenz JB, Litvan I, Richard I, Siderowf A, Coffey CS, Simuni T, Weintraub D, Initiative T. Cognition among individuals along a spectrum of increased risk for Parkinson’s disease. PLOS ONE 2018, 13: e0201964. PMID: 30125297, PMCID: PMC6101368, DOI: 10.1371/journal.pone.0201964.Peer-Reviewed Original ResearchConceptsParkinson's diseaseIdiopathic REM sleep behavior disorderParkinson's Progression Markers Initiative (PPMI) studyDe novo Parkinson's diseaseREM sleep behavior disorderDopamine transporterNon-motor symptomsNovo Parkinson's diseaseSleep behavior disorderNon-motor featuresSymbol Digit Modalities TestBaseline neuropsychological performanceMontreal Cognitive AssessmentFuture neurodegenerationLewy bodiesInclusion criteriaSpectrum of riskMutation carriersInitiative studyCohortBehavior disorderCognitive functionCognitive test scoresModalities TestNeuropsychological performanceGuanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial
Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.Peer-Reviewed Original ResearchConceptsDose of guanfacineQuality of lifeZ-scoreCognitive functionPrefrontal cognitive dysfunctionCommon adverse eventsPrimary outcome measureRandomized clinical trialsGlobal functionOlder participantsHealthy older participantsPrefrontal cognitive functionDry mouthAdverse eventsAgonist guanfacineClinical trialsGuanfacine treatmentCognitive dysfunctionMean changeOutcome measuresPlaceboGuanfacineOlder individualsWeeksDoseA New Measure for Neural Compensation Is Positively Correlated With Working Memory and Gait Speed
Ji L, Pearlson GD, Hawkins KA, Steffens DC, Guo H, Wang L. A New Measure for Neural Compensation Is Positively Correlated With Working Memory and Gait Speed. Frontiers In Aging Neuroscience 2018, 10: 71. PMID: 29615893, PMCID: PMC5868123, DOI: 10.3389/fnagi.2018.00071.Peer-Reviewed Original ResearchHigher cognitive reserveCognitive reserveNeural compensationOlder adultsFace-name memory taskHigh cognitive demand tasksCompensatory abilityMemory task performanceTask-activated networksLow cognitive reserveHealthy older adultsSpatial independent component analysisStructural magnetic resonance imaging (MRI) scansNeural resourcesWorking memoryMemory taskCognitive tasksMemory performanceCognitive engagementIndependent component analysisTask performanceNeural activationCognitive functionBrain functionPrior research
2010
Changes in Memory Function and Neuronal Activation Associated with Atorvastatin Therapy
Parker B, Polk D, Rabdiya V, Meda S, Anderson K, Hawkins K, Pearlson G, Thompson P. Changes in Memory Function and Neuronal Activation Associated with Atorvastatin Therapy. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2010, 30: 625-625. DOI: 10.1592/phco.30.6.625.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingCognitive complaintsCognitive test performanceMemory taskCognitive testsFMRI findingsFMRI patternsCognitive testingCognitive functionMemory functionCognitive symptomsMemory impairmentTest performanceNeuronal activationBrain functionPreliminary evidenceObjective measuresMemory lossPsychiatric problemsAtorvastatin therapyMajor head traumaFirst case reportDays of cessationCentral nervous systemAlcohol consumption
2006
Light to Moderate Alcohol Consumption Is Associated With Better Cognitive Function Among Older Male Veterans Receiving Primary Care
Reid MC, Van Ness PH, Hawkins KA, Towle V, Concato J, Guo Z. Light to Moderate Alcohol Consumption Is Associated With Better Cognitive Function Among Older Male Veterans Receiving Primary Care. Journal Of Geriatric Psychiatry And Neurology 2006, 19: 98-105. PMID: 16690995, DOI: 10.1177/0891988706286513.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionOlder male veteransBetter cognitive functionCognitive functionFormer drinkersPrimary careMale veteransModerate drinkingAlcohol consumptionBetter cognitive performanceOlder personsVeterans Administration primary care clinicCognitive performancePrimary care clinicsHopkins Verbal Learning TestCare clinicsVerbal Learning TestMean ageCurrent drinkersMedical statusOlder menReference groupLifetime useLearning TestDrinkers
2004
Who Can Stay at Home?: Assessing the Capacity to Choose to Live in the Community
Cooney LM, Kennedy GJ, Hawkins KA, Hurme SB. Who Can Stay at Home?: Assessing the Capacity to Choose to Live in the Community. JAMA Internal Medicine 2004, 164: 357-360. PMID: 14980985, DOI: 10.1001/archinte.164.4.357.Peer-Reviewed Original ResearchConceptsExecutive functionUnsafe actionsDecision-making abilityProblem-solving abilityCognitive functionImpaired insightPerson's capacityChoices of individualsIndependent livingOlder individualsSocial agencyDeficitsIndividualsAbilityPlanning limitsDecisionsMedical decisionsImplicationsActionFinal responsibilityGlobal testChoiceResponsibility