Frequent Cocaine Use is Associated With Larger HIV Latent Reservoir Size
Aouizerat B, Garcia J, Domingues C, Xu K, Quach B, Page G, Konkle-Parker D, Bolivar H, Lahiri C, Golub E, Cohen M, Kassaye S, DeHovitz J, Kuniholm M, Archin N, Tien P, Hancock D, Johnson E. Frequent Cocaine Use is Associated With Larger HIV Latent Reservoir Size. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 97: 156-164. PMID: 39250649, DOI: 10.1097/qai.0000000000003472.Peer-Reviewed Original ResearchHIV latent reservoirImpact of cocaine useCocaine useT cellsAssociated with higher HIV viral loadHigher HIV viral loadSelf-reported cocaine useHIV DNA assaysLatent reservoir sizeRapid HIV progressionVirologically suppressed womenHIV viral loadFrequent cocaine useVirally suppressed PLWHHistory of HIVLatent reservoirAntiretroviral therapyHIV progressionLongitudinal cohort studyViral loadCocaine usersNever usersIntact provirusesCohort studyCD4Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts
Zhang X, Hu Y, Vandenhoudt R, Yan C, Marconi V, Cohen M, Wang Z, Justice A, Aouizerat B, Xu K. Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts. PLOS Pathogens 2024, 20: e1012063. PMID: 38466776, PMCID: PMC10957090, DOI: 10.1371/journal.ppat.1012063.Peer-Reviewed Original ResearchCD4+ T cellsEpigenome-wide association studiesPeripheral blood mononuclear cellsHIV infectionHIV pathogenesisT cellsCpG sitesNatural killer (NK) cellsCell typesAssociated with HIV infectionCD8+ T cellsMethylation patternsCpG methylationDNA methylationEpigenome-wide DNA methylation analysisBlood mononuclear cellsImmune cell typesDifferentially methylated CpG sitesUnique CpG sitesDifferential CpG methylationDNA methylation analysisSignificant CpG sitesArray-based methodsGene set enrichment analysisComputational deconvolution methods