1999
p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex
Romanelli A, Martin K, Toker A, Blenis J. p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex. Molecular And Cellular Biology 1999, 19: 2921-2928. PMID: 10082559, PMCID: PMC84086, DOI: 10.1128/mcb.19.4.2921.Peer-Reviewed Original ResearchConceptsP70 S6 kinasePDK-1Protein kinase CS6 kinaseGrowth factor-independent mannerK activationPhosphoinositide-dependent kinase 1Atypical protein kinase CC-terminal truncation mutantsPDK-1 activationProtein kinase CζFactor-independent mannerThreonine 389Pseudosubstrate domainSignaling ComplexGrowth factorSequential phosphorylationTruncation mutantsCoexpression experimentsEpidermal growth factorCatalytic loopUpstream regulatorKinase 1PKC isoformsKinase C
1998
Structural interactions between chemokine receptors, gp120 Env and CD4
Choe H, Martin K, Farzan M, Sodroski J, GERARD N, Gerard C. Structural interactions between chemokine receptors, gp120 Env and CD4. Seminars In Immunology 1998, 10: 249-257. PMID: 9653051, DOI: 10.1006/smim.1998.0127.Peer-Reviewed Original ResearchConceptsHIV-1SIV isolatesChemokine receptorsBeta-chemokine receptor CCR5Laboratory-adapted HIV-1Late-stage HIV infectionPrimary HIV-1HIV-1 entryGp120 EnvSIV infectionViral envelope glycoproteinsHIV infectionChronic phaseHIV-2Receptor CCR5SIV virusInfectionEnvelope glycoproteinTransmembrane segment receptorsReceptorsCD4Molecular determinantsDependent sitesHIVCCR5