2011
Prostacyclin receptor regulation--from transcription to trafficking.
Midgett C, Stitham J, Martin K, Hwa J. Prostacyclin receptor regulation--from transcription to trafficking. 2011, 11: 517-28. PMID: 21707517, PMCID: PMC3647249, DOI: 10.2174/156652411800615144.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMouse knockout studiesReceptor regulationTransmembrane G-proteinKnockout studiesG proteinsCell surfaceRegulatory processesNon-selective COX-1/COXCorrect functionTranscriptionHigh cardiovascular risk patientsImportant receptorProstacyclin receptorImportant cardioprotective rolePrevention of atherothrombosisCardiovascular risk patientsIncreased cardiovascular eventsCOX-1/COXRegulationReceptorsCardiovascular eventsRisk patientsReceptor dysfunctionCardioprotective roleIP receptor
1998
The Orphan Seven-Transmembrane Receptor Apj Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human Immunodeficiency Virus Type 1
Choe H, Farzan M, Konkel M, Martin K, Sun Y, Marcon L, Cayabyab M, Berman M, Dorf M, Gerard N, Gerard C, Sodroski J. The Orphan Seven-Transmembrane Receptor Apj Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human Immunodeficiency Virus Type 1. Journal Of Virology 1998, 72: 6113-6118. PMID: 9621075, PMCID: PMC110417, DOI: 10.1128/jvi.72.7.6113-6118.1998.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1T cell line tropicType 1Peripheral blood mononuclear cellsHIV-1 infectionHIV-1 isolatesBlood mononuclear cellsHIV-1 coreceptorsChemokine receptor CCR5Such coreceptorsMononuclear cellsAsymptomatic stageReceptor APJReceptor CCR5HIV-1Infected individualsCoreceptorAPJTarget cellsInfectionReceptorsViral evolutionSIVmac316Structural interactions between chemokine receptors, gp120 Env and CD4
Choe H, Martin K, Farzan M, Sodroski J, GERARD N, Gerard C. Structural interactions between chemokine receptors, gp120 Env and CD4. Seminars In Immunology 1998, 10: 249-257. PMID: 9653051, DOI: 10.1006/smim.1998.0127.Peer-Reviewed Original ResearchConceptsHIV-1SIV isolatesChemokine receptorsBeta-chemokine receptor CCR5Laboratory-adapted HIV-1Late-stage HIV infectionPrimary HIV-1HIV-1 entryGp120 EnvSIV infectionViral envelope glycoproteinsHIV infectionChronic phaseHIV-2Receptor CCR5SIV virusInfectionEnvelope glycoproteinTransmembrane segment receptorsReceptorsCD4Molecular determinantsDependent sitesHIVCCR5