2011
Prostacyclin receptor regulation--from transcription to trafficking.
Midgett C, Stitham J, Martin K, Hwa J. Prostacyclin receptor regulation--from transcription to trafficking. 2011, 11: 517-28. PMID: 21707517, PMCID: PMC3647249, DOI: 10.2174/156652411800615144.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMouse knockout studiesReceptor regulationTransmembrane G-proteinKnockout studiesG proteinsCell surfaceRegulatory processesNon-selective COX-1/COXCorrect functionTranscriptionHigh cardiovascular risk patientsImportant receptorProstacyclin receptorImportant cardioprotective rolePrevention of atherothrombosisCardiovascular risk patientsIncreased cardiovascular eventsCOX-1/COXRegulationReceptorsCardiovascular eventsRisk patientsReceptor dysfunctionCardioprotective roleIP receptor
2009
Adiponectin Induces Vascular Smooth Muscle Cell Differentiation via AMPK
Ding M, Wagner R, Fetalvero K, Kasza Z, Powell R, Martin K. Adiponectin Induces Vascular Smooth Muscle Cell Differentiation via AMPK. The FASEB Journal 2009, 23: 577.10-577.10. DOI: 10.1096/fasebj.23.1_supplement.577.10.Peer-Reviewed Original ResearchMTOR inhibitionLower adiponectin levelsVSMC differentiationType 2 diabetesVascular smooth muscle cell phenotypeSmooth muscle cell phenotypeAMPK activationDose-dependent mannerContractile protein expressionAMPK inhibitor compound C.Muscle cell phenotypeVascular smooth muscle cell differentiationVSMC contractile phenotypeAdipo-R1Smooth muscle cell differentiationAdiponectin levelsSerum hormonesCardioprotective roleHormonal inhibitorCardiovascular diseaseAdiponectinCardioprotective functionControl virusEndothelial cellsVSMC