2018
Immunotherapy in selected patients with Down syndrome disintegrative disorder
Cardinale KM, Bocharnikov A, Hart SJ, Baker JA, Eckstein C, Jasien JM, Gallentine W, Worley G, Kishnani PS, Van Mater H. Immunotherapy in selected patients with Down syndrome disintegrative disorder. Developmental Medicine & Child Neurology 2018, 61: 847-851. PMID: 30548468, DOI: 10.1111/dmcn.14127.Peer-Reviewed Original ResearchConceptsCognitive declineDisintegrative disorderDown syndromeHistory of autoimmunitySmall case seriesAutoimmune thyroid diseaseSymptoms of catatoniaAdditional immunotherapyIntravenous immunoglobulinCase seriesMedical recordsThyroid diseaseImmunotherapyPAPER ADDSPatientsCatatoniaInsomniaCore symptomsPsychosisAutistic featuresYoung adultsSymptomsAutoimmunityDisordersSyndromeAn Update on the Treatment of Pediatric Autoimmune Encephalitis
Stingl C, Cardinale K, Van Mater H. An Update on the Treatment of Pediatric Autoimmune Encephalitis. Current Treatment Options In Rheumatology 2018, 4: 14-28. PMID: 29780690, PMCID: PMC5957495, DOI: 10.1007/s40674-018-0089-z.Peer-Reviewed Original ResearchSecond-line therapyRefractory diseaseNeuropsychiatric deficitsProspective randomized placebo-controlled trialInterleukin-6 inhibitor tocilizumabLow-dose IL-2Randomized placebo-controlled trialPediatric autoimmune encephalitisPlacebo-controlled trialEarly treatment initiationFirst-line therapyFirst-line treatmentSecond-line agentsIL-6 blockadeMajority of patientsProteasome inhibitorsRecent FindingsTo dateAutoimmune encephalitisTreatment escalationIntravenous immunoglobulinMycophenolate mofetilClinical improvementPharmacologic treatmentPrompt treatmentTreatment initiation
2012
Acetylcholinesterase inhibition ameliorates deficits in motivational drive
Martinowich K, Cardinale KM, Schloesser RJ, Hsu M, Greig NH, Manji HK. Acetylcholinesterase inhibition ameliorates deficits in motivational drive. Behavioral And Brain Functions 2012, 8: 15. PMID: 22433906, PMCID: PMC3328273, DOI: 10.1186/1744-9081-8-15.Peer-Reviewed Original ResearchMeSH KeywordsAnhedoniaAnimalsAnxietyBehavior, AnimalBody WeightCholinesterase InhibitorsChronic DiseaseDriveHabituation, PsychophysiologicHindlimb SuspensionImage Processing, Computer-AssistedImmunohistochemistryMaleMiceMice, Inbred C57BLMotivationNervous SystemPhenotypePhysostigmineProto-Oncogene Proteins c-fosQuinineRestraint, PhysicalStress, PsychologicalSwimmingTasteConceptsChronic restraint stress protocolRestraint stress protocolCholinergic basal forebrain systemApathetic behaviorRecent clinical trialsBasal forebrain systemNeuronal activity patternsNumerous neurological disordersFosB immunohistochemistryClinical trialsCholinergic systemMedial septumNucleus accumbensCRS protocolImmediate early gene activationForebrain systemNeurological disordersNeuropsychiatric disordersMotivational driveStress protocolEarly gene activationAnticholinesteraseAcetylcholinesterase inhibitionDeficitsRemediation of deficits