Acetylcholinesterase inhibition ameliorates deficits in motivational drive
Martinowich K, Cardinale KM, Schloesser RJ, Hsu M, Greig NH, Manji HK. Acetylcholinesterase inhibition ameliorates deficits in motivational drive. Behavioral And Brain Functions 2012, 8: 15. PMID: 22433906, PMCID: PMC3328273, DOI: 10.1186/1744-9081-8-15.Peer-Reviewed Original ResearchMeSH KeywordsAnhedoniaAnimalsAnxietyBehavior, AnimalBody WeightCholinesterase InhibitorsChronic DiseaseDriveHabituation, PsychophysiologicHindlimb SuspensionImage Processing, Computer-AssistedImmunohistochemistryMaleMiceMice, Inbred C57BLMotivationNervous SystemPhenotypePhysostigmineProto-Oncogene Proteins c-fosQuinineRestraint, PhysicalStress, PsychologicalSwimmingTasteConceptsChronic restraint stress protocolRestraint stress protocolCholinergic basal forebrain systemApathetic behaviorRecent clinical trialsBasal forebrain systemNeuronal activity patternsNumerous neurological disordersFosB immunohistochemistryClinical trialsCholinergic systemMedial septumNucleus accumbensCRS protocolImmediate early gene activationForebrain systemNeurological disordersNeuropsychiatric disordersMotivational driveStress protocolEarly gene activationAnticholinesteraseAcetylcholinesterase inhibitionDeficitsRemediation of deficits