2021
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
Ovadia C, Sajous J, Seed PT, Patel K, Williamson NJ, Attilakos G, Azzaroli F, Bacq Y, Batsry L, Broom K, Brun-Furrer R, Bull L, Chambers J, Cui Y, Ding M, Dixon PH, Estiú MC, Gardiner FW, Geenes V, Grymowicz M, Günaydin B, Hague WM, Haslinger C, Hu Y, Indraccolo U, Juusela A, Kane SC, Kebapcilar A, Kebapcilar L, Kohari K, Kondrackienė J, Koster MPH, Lee RH, Liu X, Locatelli A, Macias RIR, Madazli R, Majewska A, Maksym K, Marathe JA, Morton A, Oudijk MA, Öztekin D, Peek MJ, Shennan AH, Tribe RM, Tripodi V, Özterlemez N, Vasavan T, Wong LFA, Yinon Y, Zhang Q, Zloto K, Marschall HU, Thornton J, Chappell LC, Williamson C. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology 2021, 6: 547-558. PMID: 33915090, PMCID: PMC8192305, DOI: 10.1016/s2468-1253(21)00074-1.Peer-Reviewed Original ResearchMeSH KeywordsCholagogues and CholereticsCholestasis, IntrahepaticFemaleHumansPregnancyPregnancy ComplicationsUrsodeoxycholic AcidConceptsUrsodeoxycholic acid treatmentPrevalence of stillbirthIndividual participant dataIntrahepatic cholestasisBile acid concentrationsUrsodeoxycholic acidComposite outcomeParticipant dataPerinatal outcomesPreterm birthSystematic reviewIndividual participant data analysisLow overall event rateComposite of stillbirthMain secondary outcomesUnpublished cohort studiesAdverse perinatal outcomesMore study participantsOverall event rateTwo-arm studyWeb of ScienceCohort studySecondary outcomesSingleton pregnanciesPrimary outcome
2016
Outcome after implementation of a modern management strategy for intrahepatic cholestasis of pregnancy
Kohari KS, Carroll R, Capogna S, Ditchik A, Fox NS, Ferrara LA. Outcome after implementation of a modern management strategy for intrahepatic cholestasis of pregnancy. The Journal Of Maternal-Fetal & Neonatal Medicine 2016, 30: 1342-1346. PMID: 27418248, DOI: 10.1080/14767058.2016.1212833.Peer-Reviewed Original ResearchConceptsNeonatal outcomesIntrahepatic cholestasisBile acidsContinuous fetal heart rate monitoringModern management strategiesGreater maternal ageRetrospective cohort studyFetal heart rate monitoringCesarean delivery rateTotal bile acidsNew management protocolNew cohortNICU admissionGestational diabetesSingleton gestationsCohort studyPatient demographicsPregnancy outcomesInpatient admissionsMaternal ageHeart rate monitoringStillbirth rateWeeksCholestasisOutcomes