2024
Rate of clinically significant red blood cell antibody seroconversion in pregnancy
Ding J, Abels E, Jacobs J, Culhane J, Lundsberg L, Partridge C, Denoble A, Kohari K. Rate of clinically significant red blood cell antibody seroconversion in pregnancy. The Journal Of Maternal-Fetal & Neonatal Medicine 2024, 37: 2419370. PMID: 39462637, DOI: 10.1080/14767058.2024.2419370.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitAdvanced maternal ageAssociated with seroconversionClinically significant antibodiesAntibody screeningNeonatal outcomesIncreasing gravidityAntibody seroconversionInitial hemoglobinMaternal ageSignificant antibodiesAntibody statusNeonatal intensive care unit admissionCohort studyClinically significant RBC antibodiesAnti-CUnexplained fetal lossPositive antibody screenNegative antibody screenCases of stillbirthRetrospective cohort studyIntensive care unitWilcoxon rank-sumMaternal antibody statusPostnatal transfusion
2021
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
Ovadia C, Sajous J, Seed PT, Patel K, Williamson NJ, Attilakos G, Azzaroli F, Bacq Y, Batsry L, Broom K, Brun-Furrer R, Bull L, Chambers J, Cui Y, Ding M, Dixon PH, Estiú MC, Gardiner FW, Geenes V, Grymowicz M, Günaydin B, Hague WM, Haslinger C, Hu Y, Indraccolo U, Juusela A, Kane SC, Kebapcilar A, Kebapcilar L, Kohari K, Kondrackienė J, Koster MPH, Lee RH, Liu X, Locatelli A, Macias RIR, Madazli R, Majewska A, Maksym K, Marathe JA, Morton A, Oudijk MA, Öztekin D, Peek MJ, Shennan AH, Tribe RM, Tripodi V, Özterlemez N, Vasavan T, Wong LFA, Yinon Y, Zhang Q, Zloto K, Marschall HU, Thornton J, Chappell LC, Williamson C. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology 2021, 6: 547-558. PMID: 33915090, PMCID: PMC8192305, DOI: 10.1016/s2468-1253(21)00074-1.Peer-Reviewed Original ResearchConceptsUrsodeoxycholic acid treatmentPrevalence of stillbirthIndividual participant dataIntrahepatic cholestasisBile acid concentrationsUrsodeoxycholic acidComposite outcomeParticipant dataPerinatal outcomesPreterm birthSystematic reviewIndividual participant data analysisLow overall event rateComposite of stillbirthMain secondary outcomesUnpublished cohort studiesAdverse perinatal outcomesMore study participantsOverall event rateTwo-arm studyWeb of ScienceCohort studySecondary outcomesSingleton pregnanciesPrimary outcome
2018
Impact of Prior History of Intrahepatic Cholestasis of Pregnancy on Current Pregnancy [33K]
Kohari K, Rekawek P, Lipkind H, Ferrara L. Impact of Prior History of Intrahepatic Cholestasis of Pregnancy on Current Pregnancy [33K]. Obstetrics And Gynecology 2018, 131: 127s-128s. DOI: 10.1097/01.aog.0000533535.05918.b3.Peer-Reviewed Original ResearchHistory of ICPAdverse neonatal outcomesPrior historyNeonatal outcomesMaternal demographicsIntrahepatic cholestasisDiagnosis of ICPRetrospective cohort studyHigh rateMultiparous pregnanciesPregnancy expectationsMultiparous patientsPregnancy coursePrior pregnancyCohort studyCurrent pregnancyLow birthweightSingle hospitalICP managementEarly diagnosisPatientsPregnancyOverall oddsLogistic regressionDelivery timing
2016
Outcome after implementation of a modern management strategy for intrahepatic cholestasis of pregnancy
Kohari KS, Carroll R, Capogna S, Ditchik A, Fox NS, Ferrara LA. Outcome after implementation of a modern management strategy for intrahepatic cholestasis of pregnancy. The Journal Of Maternal-Fetal & Neonatal Medicine 2016, 30: 1342-1346. PMID: 27418248, DOI: 10.1080/14767058.2016.1212833.Peer-Reviewed Original ResearchConceptsNeonatal outcomesIntrahepatic cholestasisBile acidsContinuous fetal heart rate monitoringModern management strategiesGreater maternal ageRetrospective cohort studyFetal heart rate monitoringCesarean delivery rateTotal bile acidsNew management protocolNew cohortNICU admissionGestational diabetesSingleton gestationsCohort studyPatient demographicsPregnancy outcomesInpatient admissionsMaternal ageHeart rate monitoringStillbirth rateWeeksCholestasisOutcomes