Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis
Foer D, Zhu M, Cardone RL, Simpson C, Sullivan R, Nemiroff S, Lee G, Kibbey RG, Petersen KF, Insogna KL. Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis. Osteoporosis International 2017, 28: 2011-2017. PMID: 28283687, PMCID: PMC6693506, DOI: 10.1007/s00198-017-3977-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood GlucoseCase-Control StudiesCholesterol, LDLFemaleGain of Function MutationGlucose Tolerance TestGlycated HemoglobinHomeostasisHumansIslets of LangerhansLipid MetabolismLow Density Lipoprotein Receptor-Related Protein-5MaleMiddle AgedTissue Culture TechniquesWnt Signaling PathwayConceptsLow-density lipoprotein receptor-related protein 5Insulin sensitivity indexType 2 diabetesInsulin secretionLRP5 mutationsLipid metabolismSerum LDLInsulin sensitivityLipid homeostasisGlucose metabolismAnimal modelsMean insulin sensitivity indexFunction mutationsHigh bone mass phenotypeLipoprotein receptor-related protein 5Augment insulin secretionGlucose-stimulated insulin secretionCoronary artery diseaseMajor risk factorCase-control studyImpaired insulin sensitivityHepatic lipid contentBone mass phenotypeProton magnetic resonance spectroscopyAcademic medical center