2004
The expanding role of PI3-kinase in bone
Golden LH, Insogna KL. The expanding role of PI3-kinase in bone. Bone 2004, 34: 3-12. PMID: 14751558, DOI: 10.1016/j.bone.2003.09.005.BooksMeSH KeywordsAnimalsBone and BonesHumansMiceMice, TransgenicOsteoblastsPhosphatidylinositol 3-KinasesSignal TransductionConceptsRole of PI3PI3-KsC-fmsTyrosine kinase c-SrcKinase c-SrcDifferent substrate specificitiesCritical downstream effectorCell surface receptorsActin remodelingSignal transductionPI3-kinaseC-SrcSubstrate specificityDownstream effectorsOsteoblast differentiationCellular responsesPI3Attachment structuresEffector actionOsteoclast survivalRegulationRecent evidenceImportant roleTransductionRole
2000
Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1.
Grey A, Chen Y, Paliwal I, Carlberg K, Insogna K. Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1. Endocrinology 2000, 141: 2129-38. PMID: 10830300, DOI: 10.1210/endo.141.6.7480.Peer-Reviewed Original ResearchAndrostadienesAnimalsBinding SitesCell MovementChromonesEnzyme InhibitorsImmunosorbent TechniquesMacrophage Colony-Stimulating FactorMiceMorpholinesOsteoclastsPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProlineProto-Oncogene Proteins pp60(c-src)RatsReceptor, Macrophage Colony-Stimulating FactorRegulatory Sequences, Nucleic AcidSrc Homology DomainsWortmannin