2010
Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial
Wright MJ, Sullivan RR, Gaffney‐Stomberg E, Caseria DM, O'Brien KO, Proctor DD, Simpson CA, Kerstetter JE, Insogna KL. Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial. Journal Of Bone And Mineral Research 2010, 25: 2205-2211. PMID: 20499372, PMCID: PMC3312746, DOI: 10.1002/jbmr.108.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionProton pump inhibitorsCalcium absorptionGastric acidDual-stable calcium isotopesYoung adultsChronic PPI therapyPotent gastric acidGastric acid suppressionNegative calcium balanceGastric acid productionHealthy young adultsPPI esomeprazolePPI therapyPlacebo groupUrinary calciumAcid suppressionCrossover studyBone lossPump inhibitorsClinical trialsIntervention periodAcute effectsCalcium balanceHealthy individuals
2009
The Effect of Proton Pump-Inhibiting Drugs on Mineral Metabolism
Insogna KL. The Effect of Proton Pump-Inhibiting Drugs on Mineral Metabolism. The American Journal Of Gastroenterology 2009, 104: ajg200944. PMID: 19262542, DOI: 10.1038/ajg.2009.44.BooksConceptsProton pump inhibitorsMineral metabolismLong-term proton pump inhibitorsIntestinal calcium absorptionHip fracture ratesClass of drugsFragility fracturesBone lossCalcium economyPump inhibitorsCalcium absorptionFracture ratesCalcium balanceSkeletal homeostasisGreater riskAdverse effectsHigh rateDrugsRecent studiesMetabolismLong term
2008
Proton pump-inhibiting drugs, calcium homeostasis, and bone health
Wright MJ, Proctor DD, Insogna KL, Kerstetter JE. Proton pump-inhibiting drugs, calcium homeostasis, and bone health. Nutrition Reviews 2008, 66: 103-108. PMID: 18254877, DOI: 10.1111/j.1753-4887.2008.00015.x.Books