2018
Associations among circulating colony-stimulating factor-1, estrogen, and bone mineral density in postmenopausal women
Haas AV, Cong E, Simpson CA, Sukumar N, Deng Y, Insogna KL. Associations among circulating colony-stimulating factor-1, estrogen, and bone mineral density in postmenopausal women. Menopause The Journal Of The North American Menopause Society 2018, 25: 197-201. PMID: 28816930, DOI: 10.1097/gme.0000000000000974.Peer-Reviewed Original ResearchConceptsBone mineral densityEstrogen-deficient womenMineral densityBone lossColony-stimulating factor-1Kronos Early Estrogen Prevention StudyPostmenopausal bone lossPlacebo-controlled studyOsteoclastic bone resorptionFactor 1CSF-1 levelsCSF-1Estrogen replacementEstrogen therapyPlacebo groupPostmenopausal womenCardiovascular endpointsSerum levelsFemoral neckBone resorptionPrevention StudyAncillary studiesTreatment groupsWomenSignificant correlation
2017
Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation 1 , 2
Shams-White MM, Chung M, Du M, Fu Z, Insogna KL, Karlsen MC, LeBoff MS, Shapses SA, Sackey J, Wallace TC, Weaver CM. Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation 1 , 2. American Journal Of Clinical Nutrition 2017, 105: 1528-1543. PMID: 28404575, DOI: 10.3945/ajcn.116.145110.Peer-Reviewed Original ResearchConceptsBone mineral densityHigh protein intakeProspective cohort studyProtein intakeSystematic reviewCohort studyBone healthTotal hipFemoral neckModerate evidenceLumbar spine bone mineral densityTotal body bone mineral densityTH bone mineral densityLS bone mineral densityBody bone mineral densitySpine bone mineral densityFN bone mineral densityBone health measuresBone health outcomesDietary proteinLow protein intakeFull-text screeningStrength of evidenceOverall RoBNonpharmacologic approachesANIMAL VERSUS PLANT PROTEIN INTAKE AND BONE HEALTH‐A SYSTEMATIC REVIEW AND META‐ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Shams‐White M, Fu Z, Karlsen M, Sackey J, Shi J, Insogna K, LeBoff M, Shapses S, Weaver C, Wallace T, Chung M. ANIMAL VERSUS PLANT PROTEIN INTAKE AND BONE HEALTH‐A SYSTEMATIC REVIEW AND META‐ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.139.3.Peer-Reviewed Original ResearchBone-specific alkaline phosphataseBone mineral densityPlant protein intakeBone mineral contentRandomized controlled trialsPost-menopausal womenProtein intakeLumbar spineTotal bodyFemoral neckCollagen type 1 cross-linked C-telopeptideCross-linked C-telopeptideBone mineral density outcomesTotal hipCross-linked N-telopeptideMeta-analysis of randomized controlled trialsTB bone mineral contentControlled trialsSystematic reviewLow statistical heterogeneityMeta-analysisBone health outcomesHealthy adultsRandom-effects meta-analysesEffects meta-analyses
2016
Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy
Knobf MT, Jeon S, Smith B, Harris L, Kerstetter J, Thompson AS, Insogna K. Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy. Breast Cancer Research And Treatment 2016, 155: 491-500. PMID: 26850265, DOI: 10.1007/s10549-016-3693-3.Peer-Reviewed Original ResearchConceptsFemale cancer survivorsPhysical activity groupEndocrine therapyBone outcomesExercise interventionBone lossFemoral neckAromatase inhibitorsActivity groupAdjuvant AI therapyChemotherapy-induced menopauseSufficient serum levelsAdjuvant endocrine therapyVitamin D supplementsHealthy postmenopausal womenLess bone lossHome-based groupSignificant BMD lossSignificant clinical problemMajority of subjectsAI therapyD supplementsPostmenopausal womenBMD lossBMD outcomes
2013
An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey years 2005–2008
Mangano KM, Kerstetter JE, Kenny AM, Insogna KL, Walsh SJ. An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey years 2005–2008. Osteoporosis International 2013, 25: 1033-1041. PMID: 24121998, PMCID: PMC3969769, DOI: 10.1007/s00198-013-2501-8.Peer-Reviewed Original ResearchConceptsSpine bone mineral densityLumbar spine bone mineral densityBone mineral densityTotal femur bone mineral densityFemoral neck bone mineral densityFemur bone mineral densityNeck bone mineral densityFA supplement useSupplement useMineral densityFemoral neckNational HealthOlder adultsDietary omega-3 fatty acid intakeGreater femoral neck BMDHigher spine bone mineral densityHigher lumbar spine bone mineral densityOmega-3 fatty acid intakeDietary omega 3 FAHip bone mineral densityOmega-3 intakeFatty acid intakeNutrition Examination SurveyOmega-3 FAMultivariable regression models