2024
Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis
Ibrahim K, Iturmendi-Sabater I, Vasishth M, Barron D, Guardavaccaro M, Funaro M, Holmes A, McCarthy G, Eickhoff S, Sukhodolsky D. Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis. Schizophrenia Research 2024, 264: 298-313. PMID: 38215566, PMCID: PMC10922721, DOI: 10.1016/j.schres.2023.12.003.Peer-Reviewed Original ResearchConceptsRight inferior frontal gyrusAutism spectrum disorderInferior frontal gyrusEye gaze processingActivation likelihood estimationRight fusiform gyrusGaze processingFrontal gyrusFusiform gyrusFrontotemporal circuitryFunctional decodingSpectrum disorderActivation likelihood estimation meta-analysisMeta-analytic connectivity modelingMeta-analytic connectivityNeural circuit disruptionsTransdiagnostic biomarkerEmotional processingLeft amygdalaNeurobiological dysfunctionSocial cognitionEmotion perceptionNeural mechanismsSchizophreniaSpatial cognition
2022
Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment
Ibrahim K, Kalvin C, Morand-Beaulieu S, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment. Cerebral Cortex 2022, 32: 4371-4385. PMID: 35059702, PMCID: PMC9574236, DOI: 10.1093/cercor/bhab489.Peer-Reviewed Original ResearchConceptsSocial impairmentPrefrontal cortexEmotion processingMaladaptive aggressionAggressive behaviorSocial deficitsEmotion perception taskImplicit emotion processingFace emotion processingFunctional magnetic resonance imagingGreater social impairmentAmygdala-prefrontal connectivityChildhood-onset psychiatric disordersVentral prefrontal cortexDorsolateral prefrontal cortexFearful facesSocial cognitionPerception taskCalm facesSocial cuesTransdiagnostic sampleAmygdala reactivityParent ratingsPFC connectivityDiminished connectivity
2021
Social cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorder
Ibrahim K, Soorya LV, Halpern DB, Gorenstein M, Siper PM, Wang AT. Social cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorder. Autism Research 2021, 14: 2495-2511. PMID: 34486810, DOI: 10.1002/aur.2603.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMedial prefrontal cortexTheory of mindSocial skills groupsSchool-aged childrenSkill groupsSocial cognitionIrony comprehensionSkills interventionSpectrum disorderSocial functioningMedial prefrontal cortex activityComparison groupIrony Comprehension TaskSocial cognitive skillsEye gaze processingSocial skills interventionsFunctional MRI taskSocial Responsiveness ScalePrefrontal cortex activityFirst fMRI studyChildren ages 8Whole-brain analysisActive treatment conditionsGaze processing