2017
Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis
Goodwin J, Choi H, Hsieh MH, Neugent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW. Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2017, 58: 216-231. PMID: 28915065, PMCID: PMC5805994, DOI: 10.1165/rcmb.2016-0186oc.Peer-Reviewed Original ResearchConceptsPyruvate dehydrogenase kinase 1Myofibroblast differentiationPulmonary fibrosisFibrotic progressionHIF-1αGlycolytic metabolismDehydrogenase kinase 1Knockout mouse modelHypoxia-inducible factorMetabolic reprogrammingCellular metabolismPotential therapeutic strategyKinase 1Glycolytic switchGenomic deletionsSustained activationMicroenvironmental influencesPreclinical efficacyGlycolytic reprogrammingPharmacological inhibitionReprogrammingMouse modelDifferentiationPharmacological approachesTherapeutic strategies
2016
NQO1 inhibits proteasome-mediated degradation of HIF-1α
Oh ET, Kim JW, Kim JM, Kim SJ, Lee JS, Hong SS, Goodwin J, Ruthenborg RJ, Jung MG, Lee HJ, Lee CH, Park ES, Kim C, Park HJ. NQO1 inhibits proteasome-mediated degradation of HIF-1α. Nature Communications 2016, 7: 13593. PMID: 27966538, PMCID: PMC5171868, DOI: 10.1038/ncomms13593.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCell Line, TumorColorectal NeoplasmsGene Knockdown TechniquesHomeostasisHumansHypoxia-Inducible Factor 1, alpha SubunitNAD(P)H Dehydrogenase (Quinone)OxygenProteasome Endopeptidase ComplexProtein StabilityConceptsHIF-1αColorectal cancer patient survivalNQO1 expression levelsBreast cancer cell linesOverexpression of NQO1HIF-1α expressionCancer patient survivalPro-tumorigenic capacityNQO1 knockdownCancer cell linesPro-tumorigenic functionsPatient survivalPoor prognosisHIF-1α stabilityFunction of NQO1Oxygen-dependent domainHuman colorectalMalignant progressionTumor growthNQO1CancerHIF-1Human cancersMaster transcription factorExpression levels