2024
Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children
Goodwin J, Kajubi R, Wang K, Li F, Wade M, Orukan F, Huang L, Whalen M, Aweeka F, Mwebaza N, Parikh S. Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children. Nature Communications 2024, 15: 3817. PMID: 38714692, PMCID: PMC11076639, DOI: 10.1038/s41467-024-48210-7.Peer-Reviewed Original ResearchConceptsDay 7 lumefantrine concentrationsArtemether-lumefantrine treatmentRing-stage parasitesEarly post-treatmentEarly post-treatment periodArtemether-lumefantrineArtemisinin resistanceDay regimenMulticlonal infectionsEfficacious therapyFollow-upRandomized trialsPersistent clonesTransmission settingsEffective treatmentPost-treatment periodRegimensAntimalarial studiesStandard diagnosticsStandard 3DaysPost-treatmentChildrenTreatmentTherapy
2017
A New Perspective on the Heterogeneity of Cancer Glycolysis
Neugent ML, Goodwin J, Sankaranarayanan I, Yetkin CE, Hsieh MH, Kim JW. A New Perspective on the Heterogeneity of Cancer Glycolysis. Biomolecules & Therapeutics 2017, 26: 10-18. PMID: 29212302, PMCID: PMC5746033, DOI: 10.4062/biomolther.2017.210.Peer-Reviewed Original ResearchGlucose metabolismTumor-associated stromal cellsHuman cancersDynamic metabolic interactionsElevated aerobic glycolysisClinical attemptsMetabolic targetingMolecular alterationsStromal cellsTumor metabolismCancerCentral hallmarkAerobic glycolysisCancer therapyCellular proliferationCancer glycolysisOncogenic signalingMetabolic heterogeneityMetabolismGlycolysisPhysiological functionsMetabolic interactionsMetabolic fluxMetabolic systemsTherapyLung squamous cell carcinoma exhibits a targetable glucose dependency unique among non-small cell lung cancers
Goodwin J, Neugent ML, Kim JW. Lung squamous cell carcinoma exhibits a targetable glucose dependency unique among non-small cell lung cancers. Molecular & Cellular Oncology 2017, 4: e1364211. PMID: 29057314, PMCID: PMC5644473, DOI: 10.1080/23723556.2017.1364211.Peer-Reviewed Original ResearchNon-small cell lung cancerLung squamous cell carcinomaCell lung cancerSquamous cell carcinomaCell carcinomaLung cancerGlucose dependencySubtypes of NSCLCGlucose transporter Glut1 expressionLung cancer subtypesLung cancer therapyLung adenocarcinomaGlucose metabolismMajor subtypesCancer subtypesGLUT1 expressionCancer cellsSubtypesCancer therapyCarcinomaCancerMetabolic heterogeneityGlucoseAdenocarcinomaTherapy