2007
MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia.
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly M, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander S, Le M, Larson R, Golub T, Rowley J, Chen J. MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia. Blood 2007, 110: 231. DOI: 10.1182/blood.v110.11.231.231.Peer-Reviewed Original ResearchAcute myeloid leukemiaAcute lymphoblastic leukemiaAcute leukemiaLymphoblastic leukemiaMyeloid leukemiaMiR-128aOverall survival rateExpression signaturesCommon cytogenetic subtypeMicroRNA expression signatureAcute leukemia samplesDevelopment of cancerFlow cytometric methodHuman acute leukemiaQuantitative real-time PCRReal-time PCRT cellsCytogenetic subtypesNormal controlsSurvival rateMiR-223Vivo modelLeukemiaNovel markerTarget genes
2005
MicroRNA expression profiles classify human cancers
Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. MicroRNA expression profiles classify human cancers. Nature 2005, 435: 834-838. PMID: 15944708, DOI: 10.1038/nature03702.Peer-Reviewed Original ResearchConceptsCluster of microRNAsHuman cancersHuman chromosome 13Non-coding RNAsImportant transcription factorMicroRNA expression profileTranscription factorsExpression profilesGlobal downregulationRegulatory moleculesDifferentiation statePotential oncogeneMiR-17C-MycChromosome 13MicroRNAsHuman B-cell lymphomasMicroRNA profilesTumor formationVivo modelRNANucleotidesOncogeneDownregulationExpression