2007
MicroRNA Expression Profiles in Acute Myeloid Leukemia with Common Translocations.
Li Z, Lu J, Sun M, Mi S, Zhang H, Luo R, Qian Z, Neilly M, Wang Y, Jin J, Zhang Y, Bohlander S, Larson R, LeBeau M, Thirman M, Golub T, Rowley J, Chen J. MicroRNA Expression Profiles in Acute Myeloid Leukemia with Common Translocations. Blood 2007, 110: 3181. DOI: 10.1182/blood.v110.11.3181.3181.Peer-Reviewed Original ResearchAcute myeloid leukemiaTarget genesExpression profilesDNA copy number amplificationsProtein-coding genesExpression profiling methodsImportant target genesMyeloid leukemiaNon-coding RNAsCritical target genesNormal controlsTreatment of AMLCBF acute myeloid leukemiaCopy number amplificationMiRNA expression profilesDevelopment of AMLCommon translocationEpigenetic regulationMicroRNA expression profileWide analysisComplex genetic alterationsExpression profilingDNA microarraysBiological roleTumor suppressor
2005
MicroRNA expression profiles classify human cancers
Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. MicroRNA expression profiles classify human cancers. Nature 2005, 435: 834-838. PMID: 15944708, DOI: 10.1038/nature03702.Peer-Reviewed Original ResearchConceptsCluster of microRNAsHuman cancersHuman chromosome 13Non-coding RNAsImportant transcription factorMicroRNA expression profileTranscription factorsExpression profilesGlobal downregulationRegulatory moleculesDifferentiation statePotential oncogeneMiR-17C-MycChromosome 13MicroRNAsHuman B-cell lymphomasMicroRNA profilesTumor formationVivo modelRNANucleotidesOncogeneDownregulationExpression