2021
Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway
Liu B, Zhou H, Zhang T, Gao X, Tao B, Xing H, Zhuang Z, Dardik A, Kyriakides TR, Goodwin JE. Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway. Angiogenesis 2021, 24: 631-645. PMID: 33650028, PMCID: PMC8292305, DOI: 10.1007/s10456-021-09773-x.Peer-Reviewed Original ResearchConceptsWnt/β-catenin signalingWnt/β-catenin pathwayΒ-catenin signalingΒ-catenin pathwayAutophagy fluxKey biological processesGlucocorticoid receptorNuclear receptor familyTube formation assaysEndothelial cellsBiological processesCanonical WntP62 degradationReceptor familyFormation assaysAbsence of GRCell viability assaysProcess of angiogenesisWntGR regulationSignalingVivo assaysQuantitative PCRKey receptorPathway
2019
The Glucocorticoid Receptor in Cardiovascular Health and Disease
Liu B, Zhang TN, Knight JK, Goodwin JE. The Glucocorticoid Receptor in Cardiovascular Health and Disease. Cells 2019, 8: 1227. PMID: 31601045, PMCID: PMC6829609, DOI: 10.3390/cells8101227.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorGlucocorticoid signalingCardiovascular systemNon-genomic pathwaysClinical outcomesExogenous glucocorticoidsGlucocorticoid treatmentCardiovascular healthCardiovascular diseaseNuclear receptor familyTherapeutic strategiesAnimal modelsSteroid hormone cortisolHormone cortisolPathological conditionsReceptorsDiseaseReceptor familySignalingDistinct gene networksHuman diseasesDirect effectCritical roleInflammationPrognosis