2011
ADF/Cofilin Regulates Secretory Cargo Sorting at the TGN via the Ca2+ ATPase SPCA1
von Blume J, Alleaume AM, Cantero-Recasens G, Curwin A, Carreras-Sureda A, Zimmermann T, van Galen J, Wakana Y, Valverde MA, Malhotra V. ADF/Cofilin Regulates Secretory Cargo Sorting at the TGN via the Ca2+ ATPase SPCA1. Developmental Cell 2011, 20: 652-662. PMID: 21571222, DOI: 10.1016/j.devcel.2011.03.014.Peer-Reviewed Original Research
2009
Actin remodeling by ADF/cofilin is required for cargo sorting at the trans-Golgi network
von Blume J, Duran JM, Forlanelli E, Alleaume AM, Egorov M, Polishchuk R, Molina H, Malhotra V. Actin remodeling by ADF/cofilin is required for cargo sorting at the trans-Golgi network. Journal Of Cell Biology 2009, 187: 1055-1069. PMID: 20026655, PMCID: PMC2806282, DOI: 10.1083/jcb.200908040.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkADF/cofilinActin-depolymerizing factorSecretory proteinsSecretory cargoCofilin knockdownMass spectrometry-based protein profilingMammalian tissue culture cellsGolgi-resident proteinsSorting of proteinsEndogenous secretory proteinsIntegral membrane proteinsSoluble secretory proteinsStable isotope labelingTissue culture cellsDrosophila melanogasterActin remodelingMammalian cellsMembrane proteinsGolgi membranesProtein profilingIsotope labelingCofilinCell surfaceAmino acids
2006
New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases
Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R. New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases. Molecular And Cellular Biology 2006, 26: 7086-7102. PMID: 16980613, PMCID: PMC1592903, DOI: 10.1128/mcb.00231-06.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsActive Transport, Cell NucleusAmino Acid SequenceAnimalsBinding SitesCell NucleusCells, CulturedChlorocebus aethiopsCOS CellsCytoplasmHeLa CellsHistone DeacetylasesHumansMolecular Sequence DataPhosphorylationPhosphoserineProtein Serine-Threonine KinasesProtein TransportSubstrate SpecificityConceptsMicrotubule affinity-regulating kinaseClass IIa HDACsN-terminal serine residueClass IIa histoneIIa HDACsC-TAK1IIa histoneSerine residuesMajor developmental programsMARK/ParVariety of kinasesHierarchical phosphorylationRepressive activityNuclear exportRepressive functionDevelopmental programSubcellular localizationNuclear exclusionConstitutive phosphorylationSophisticated regulationPhosphorylationKinaseSpecific signalsHDACsHistones