Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration
Moore E, Liu D, Li J, Schimmel S, Cambronero F, Terry J, Nair S, Pechman K, Moore M, Bell S, Beckman J, Gifford K, Hohman T, Blennow K, Zetterberg H, Carr J, Jefferson A. Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration. Neurology 2021, 97: e329-e340. PMID: 34031194, PMCID: PMC8362359, DOI: 10.1212/wnl.0000000000012257.Peer-Reviewed Original ResearchConceptsPulse wave velocitySynaptic dysfunctionYears of ageP-tauParticipants free of strokeMemory and Aging ProjectFramingham Stroke Risk ProfileFree of strokeT-tauAortic pulse wave velocityCommunity-based studyObservational community-based studyAssociation of aortic stiffnessStroke Risk ProfileAging ProjectOlder adultsTau phosphorylationE4 statusAlzheimer's disease pathologyHypertension statusCentral arterial stiffeningHigher aortic pulse wave velocityYKL-40Risk profileCognitive diagnosis