2021
Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers
Robb W, Khan O, Ahmed H, Li J, Moore E, Cambronero F, Pechman K, Liu D, Gifford K, Landman B, Donahue M, Hohman T, Jefferson A. Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 642-655. PMID: 34743630, PMCID: PMC9051148, DOI: 10.1177/0271678x211056393.Peer-Reviewed Original ResearchConceptsEpisodic memory performanceCognitive performancePathogenesis of Alzheimer's diseaseMemory performanceAlzheimer's disease-related neurodegenerationPoorer cognitive performanceE4 carriersLateral ventricle volumeExecutive functionEpisodic memoryOxygen homeostasisDisease-related neurodegenerationAlzheimer's diseaseBrain agingCognitive impairmentNeuroimaging variablesE4 statusCerebral metabolic rateVentricle volumeOlder adultsBad languageHippocampalNeurodegenerationMetabolic rateMetabolism
2020
Lower cerebral oxygen utilization is associated with Alzheimer’s disease‐related neurodegeneration on MRI and poorer cognitive performances among apolipoprotein E ε4 carriers
Robb W, Khan O, Ahmed H, Liu D, Moore E, Li J, Cambronero F, Pechman K, Gifford K, Landman B, Hohman T, Jefferson A. Lower cerebral oxygen utilization is associated with Alzheimer’s disease‐related neurodegeneration on MRI and poorer cognitive performances among apolipoprotein E ε4 carriers. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.046467.Peer-Reviewed Original ResearchAPOE e4 statusE4 statusModified associationsParticipants free of strokeAPOE e4 carriersFramingham Stroke Risk ProfileFree of strokeClinical Dementia RatingApolipoprotein E e4 carriersE4 carriersWorse cognitive performanceStroke Risk ProfileNeuroimaging variablesCognitive performancePoorer cognitive performanceDementia RatingGenetic risk factorsOlder adultsAlzheimer's disease-related neurodegenerationGray matter volumeAlzheimer's diseaseRisk factorsRisk profileApo E4Matter volume