2021
Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration
Moore E, Liu D, Li J, Schimmel S, Cambronero F, Terry J, Nair S, Pechman K, Moore M, Bell S, Beckman J, Gifford K, Hohman T, Blennow K, Zetterberg H, Carr J, Jefferson A. Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration. Neurology 2021, 97: e329-e340. PMID: 34031194, PMCID: PMC8362359, DOI: 10.1212/wnl.0000000000012257.Peer-Reviewed Original ResearchConceptsPulse wave velocitySynaptic dysfunctionYears of ageP-tauParticipants free of strokeMemory and Aging ProjectFramingham Stroke Risk ProfileFree of strokeT-tauAortic pulse wave velocityCommunity-based studyObservational community-based studyAssociation of aortic stiffnessStroke Risk ProfileAging ProjectOlder adultsTau phosphorylationE4 statusAlzheimer's disease pathologyHypertension statusCentral arterial stiffeningHigher aortic pulse wave velocityYKL-40Risk profileCognitive diagnosis
2020
Lower cerebral oxygen utilization is associated with Alzheimer’s disease‐related neurodegeneration on MRI and poorer cognitive performances among apolipoprotein E ε4 carriers
Robb W, Khan O, Ahmed H, Liu D, Moore E, Li J, Cambronero F, Pechman K, Gifford K, Landman B, Hohman T, Jefferson A. Lower cerebral oxygen utilization is associated with Alzheimer’s disease‐related neurodegeneration on MRI and poorer cognitive performances among apolipoprotein E ε4 carriers. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.046467.Peer-Reviewed Original ResearchAPOE e4 statusE4 statusModified associationsParticipants free of strokeAPOE e4 carriersFramingham Stroke Risk ProfileFree of strokeClinical Dementia RatingApolipoprotein E e4 carriersE4 carriersWorse cognitive performanceStroke Risk ProfileNeuroimaging variablesCognitive performancePoorer cognitive performanceDementia RatingGenetic risk factorsOlder adultsAlzheimer's disease-related neurodegenerationGray matter volumeAlzheimer's diseaseRisk factorsRisk profileApo E4Matter volume