2022
Inactivity is associated with worse cognition and neurodegeneration in aging adults
Gogniat M, Khan O, Li J, Park C, Robb W, Moore E, Houston M, Pechman K, Liu D, Hohman T, Gifford K, Jefferson A. Inactivity is associated with worse cognition and neurodegeneration in aging adults. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.067713.Peer-Reviewed Original ResearchCommunity-dwelling older adultsAPOE e4 statusEpisodic memory performanceGray matter volumeE4 statusPhysical activityOlder adultsMemory performanceMatter volumeAging adultsGenetic riskGreater physical activityAverage daily minutesIncreased physical activityFramingham Stroke Risk Profile scoreAPOE-e4 statusStratified modelsAssociated with worse cognitionCortical thicknessModifiable risk factorsTotal gray matter volumeBrain aging outcomesDays of wrist actigraphyE4 carriersParietal lobe volume
2021
Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers
Robb W, Khan O, Ahmed H, Li J, Moore E, Cambronero F, Pechman K, Liu D, Gifford K, Landman B, Donahue M, Hohman T, Jefferson A. Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 642-655. PMID: 34743630, PMCID: PMC9051148, DOI: 10.1177/0271678x211056393.Peer-Reviewed Original ResearchConceptsEpisodic memory performanceCognitive performancePathogenesis of Alzheimer's diseaseMemory performanceAlzheimer's disease-related neurodegenerationPoorer cognitive performanceE4 carriersLateral ventricle volumeExecutive functionEpisodic memoryOxygen homeostasisDisease-related neurodegenerationAlzheimer's diseaseBrain agingCognitive impairmentNeuroimaging variablesE4 statusCerebral metabolic rateVentricle volumeOlder adultsBad languageHippocampalNeurodegenerationMetabolic rateMetabolism