Inactivity is associated with worse cognition and neurodegeneration in aging adults
Gogniat M, Khan O, Li J, Park C, Robb W, Moore E, Houston M, Pechman K, Liu D, Hohman T, Gifford K, Jefferson A. Inactivity is associated with worse cognition and neurodegeneration in aging adults. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.067713.Peer-Reviewed Original ResearchCommunity-dwelling older adultsAPOE e4 statusEpisodic memory performanceGray matter volumeE4 statusPhysical activityOlder adultsMemory performanceMatter volumeAging adultsGenetic riskGreater physical activityAverage daily minutesIncreased physical activityFramingham Stroke Risk Profile scoreAPOE-e4 statusStratified modelsAssociated with worse cognitionCortical thicknessModifiable risk factorsTotal gray matter volumeBrain aging outcomesDays of wrist actigraphyE4 carriersParietal lobe volume