2024
Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts
Urie R, Morris A, Farris D, Hughes E, Xiao C, Chen J, Lombard E, Feng J, Li J, Goldstein D, Shea L. Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts. Science Advances 2024, 10: eadk6178. PMID: 38748794, PMCID: PMC11095459, DOI: 10.1126/sciadv.adk6178.Peer-Reviewed Original ResearchConceptsGraft biopsyGraft injuryRag2<sup>-/-</sup> miceAdoptive transfer of T cellsTransfer of T cellsRejection of organ allograftsAcute cellular allograft rejectionCellular allograft rejectionEfficacy of immunosuppressionPredominant innate immune cellsInnate immune cellsRisk of rejectionWild-type animalsPersonalized immunosuppressionAdoptive transferAcute rejectionOrgan allograftsAllograft rejectionFrequent biopsiesT cellsImmune cellsTransplant rejectionImmunological nicheRespiratory infectionsInflammatory insult
2023
Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice
Tyrrell D, Wragg K, Chen J, Wang H, Song J, Blin M, Bolding C, Vardaman D, Giles K, Tidwell H, Ali M, Janappareddi A, Wood S, Goldstein D. Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice. Nature Aging 2023, 3: 1576-1590. PMID: 37996758, DOI: 10.1038/s43587-023-00515-w.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsAtherosclerosisCD8-Positive T-LymphocytesHumansMemory T CellsMiceMice, Inbred C57BLPlaque, AtheroscleroticConceptsT cellsMemory CD8Aged miceAtherosclerotic plaquesDepletion of CD8Effector memory subsetsStrong risk factorT cell activationEnhanced atherosclerosisSplenic CD8Adoptive transferDonor miceMemory subsetsRecipient miceRisk factorsCD8Therapeutic targetCell activationAtherosclerosisSingle-cell RNA sequencingMiceTranscriptomic signaturesAtherogenesisPlaquesRNA sequencing