Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts
Urie R, Morris A, Farris D, Hughes E, Xiao C, Chen J, Lombard E, Feng J, Li J, Goldstein D, Shea L. Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts. Science Advances 2024, 10: eadk6178. PMID: 38748794, PMCID: PMC11095459, DOI: 10.1126/sciadv.adk6178.Peer-Reviewed Original ResearchConceptsGraft biopsyGraft injuryRag2<sup>-/-</sup> miceAdoptive transfer of T cellsTransfer of T cellsRejection of organ allograftsAcute cellular allograft rejectionCellular allograft rejectionEfficacy of immunosuppressionPredominant innate immune cellsInnate immune cellsRisk of rejectionWild-type animalsPersonalized immunosuppressionAdoptive transferAcute rejectionOrgan allograftsAllograft rejectionFrequent biopsiesT cellsImmune cellsTransplant rejectionImmunological nicheRespiratory infectionsInflammatory insult